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malaria

  • Lactic Acid Supplementation Increases Quantity and Quality of Gametocytes in <span class="named-content genus-species" id="named-content-1">Plasmodium falciparum</span> Culture
    Fungal and Parasitic Infections
    Lactic Acid Supplementation Increases Quantity and Quality of Gametocytes in Plasmodium falciparum Culture

    Malaria infection by Plasmodium falciparum continues to afflict millions of people worldwide, with transmission being dependent upon mosquito ingestion of the parasite gametocyte stage. These sexually committed stages develop from the asexual stages, yet the factors behind this transition are not completely understood. Here, we found that lactic acid increases...

    Rachel West, David J. Sullivan
  • Open Access
    Nonlethal <span class="named-content genus-species" id="named-content-1">Plasmodium yoelii</span> Infection Drives Complex Patterns of Th2-Type Host Immunity and Mast Cell-Dependent Bacteremia
    Fungal and Parasitic Infections
    Nonlethal Plasmodium yoelii Infection Drives Complex Patterns of Th2-Type Host Immunity and Mast Cell-Dependent Bacteremia

    Malaria strongly predisposes to bacteremia, which is associated with sequestration of parasitized red blood cells and increased gastrointestinal permeability. The mechanisms underlying this disruption are poorly understood. Here, we evaluated the expression of factors associated with mast cell activation and malaria-associated bacteremia in a rodent model. C57BL/6J mice were infected with...

    Nora Céspedes, Erinn Donnelly, Sarah Garrison, Lori Haapanen, Judy Van De Water, Shirley Luckhart
  • Importance of the Immunodominant CD8<sup>+</sup> T Cell Epitope of <span class="named-content genus-species" id="named-content-1">Plasmodium berghei</span> Circumsporozoite Protein in Parasite- and Vaccine-Induced Protection
    Fungal and Parasitic Infections
    Importance of the Immunodominant CD8+ T Cell Epitope of Plasmodium berghei Circumsporozoite Protein in Parasite- and Vaccine-Induced Protection

    The circumsporozoite protein (CSP) builds up the surface coat of sporozoites and is the leading malaria pre-erythrocytic-stage vaccine candidate. CSP has been shown to induce robust CD8+ T cell responses that are capable of eliminating developing parasites in hepatocytes, resulting in protective immunity. In this study, we characterized the importance of the immunodominant CSP-derived epitope SYIPSAEKI of...

    Matthew P. Gibbins, Katja Müller, Maya Glover, Jasmine Liu, Elyzana D. Putrianti, Karolis Bauza, Arturo Reyes-Sandoval, Kai Matuschewski, Olivier Silvie, Julius Clemence R. Hafalla
  • Open Access
    Microscopic and Submicroscopic Asymptomatic <span class="named-content genus-species" id="named-content-1">Plasmodium falciparum</span> Infections in Ghanaian Children and Protection against Febrile Malaria
    Fungal and Parasitic Infections
    Microscopic and Submicroscopic Asymptomatic Plasmodium falciparum Infections in Ghanaian Children and Protection against Febrile Malaria

    Naturally acquired immunity to Plasmodium falciparum malaria is thought to be nonsterile and sustained by persistence of low-level parasitemia. This study assessed the association between baseline microscopic and submicroscopic asymptomatic P. falciparum infections and antimalarial antibody levels...

    Bright Adu, Quratul-ain Issahaque, Tracy Sarkodie-Addo, Selassie Kumordjie, Eric Kyei-Baafour, Caleb K. Sinclear, Sophia Eyia-Ampah, Eunice Owusu-Yeboa, Michael Theisen, Daniel Dodoo
  • Circulating Cytokines Associated with Poor Pregnancy Outcomes in Beninese Exposed to Infection with <span class="named-content genus-species" id="named-content-1">Plasmodium falciparum</span>
    Host Response and Inflammation
    Circulating Cytokines Associated with Poor Pregnancy Outcomes in Beninese Exposed to Infection with Plasmodium falciparum

    Malaria during pregnancy is a major cause of maternal morbidity as well as fetal and neonatal mortality. Previous studies, including our own, suggested that placental and peripheral cytokine and chemokine levels measured at delivery can be used as biomarkers for pregnancy outcomes. However, the timing of malaria infection during pregnancy matters, and these studies do not address the effect of different cytokines in peripheral blood...

    Tatiana Hountohotegbe, Komi Gbedande, Gino Agbota, Samad Ibitokou, Achille Massougbodji, Philippe Deloron, Nadine Fievet, Adrian J. F. Luty
  • Early Endothelial Activation Precedes Glycocalyx Degradation and Microvascular Dysfunction in Experimentally Induced <span class="named-content genus-species" id="named-content-1">Plasmodium falciparum</span> and <span class="named-content genus-species" id="named-content-2">Plasmodium vivax</span> Infection
    Host Response and Inflammation
    Early Endothelial Activation Precedes Glycocalyx Degradation and Microvascular Dysfunction in Experimentally Induced Plasmodium falciparum and Plasmodium vivax Infection

    Endothelial activation and microvascular dysfunction are key pathogenic processes in severe malaria. We evaluated the early role of these processes in experimentally induced Plasmodium falciparum and P. vivax infection. Participants were enrolled in induced blood-stage malaria clinical trials....

    John Woodford, Tsin W. Yeo, Kim A. Piera, Kristy Butler, J. Brice Weinberg, James S. McCarthy, Nicholas M. Anstey, Bridget E. Barber
  • Peripheral Merozoite Surface Proteins Are Targets of Naturally Acquired Immunity against Malaria in both India and Ghana
    Fungal and Parasitic Infections
    Peripheral Merozoite Surface Proteins Are Targets of Naturally Acquired Immunity against Malaria in both India and Ghana

    Development of a successful blood-stage vaccine against Plasmodium falciparum malaria remains a high priority. Immune-epidemiological studies are effective tools for the identification of antigenic targets of naturally acquired immunity (NAI) against malaria. However, differences in study design and methodology may compromise interstudy comparisons.

    ...
    Asier Garcia-Senosiain, Ikhlaq Hussain Kana, Susheel Kumar Singh, Bishwanath Kumar Chourasia, Manoj Kumar Das, Daniel Dodoo, Subhash Singh, Bright Adu, Michael Theisen
  • <em>In Vivo</em> Imaging of the Buccal Mucosa Shows Loss of the Endothelial Glycocalyx and Perivascular Hemorrhages in Pediatric <span class="named-content genus-species" id="named-content-1">Plasmodium falciparum</span> Malaria
    Host Response and Inflammation
    In Vivo Imaging of the Buccal Mucosa Shows Loss of the Endothelial Glycocalyx and Perivascular Hemorrhages in Pediatric Plasmodium falciparum Malaria

    Severe malaria is mostly caused by Plasmodium falciparum, resulting in considerable, systemic inflammation and pronounced endothelial activation. The endothelium forms an interface between blood and tissue, and vasculopathy has previously been linked with malaria severity. We studied the extent to which the endothelial glycocalyx that normally maintains endothelial...

    Eric Lyimo, Lars Emil Haslund, Thomas Ramsing, Christian William Wang, Akinwale Michael Efunshile, Alphaxard Manjurano, Victor Makene, John Lusingu, Thor Grundtvig Theander, Jørgen Anders Lindholm Kurtzhals, Rasmus Paulsen, Casper Hempel
  • PD-1 Expression on NK Cells in Malaria-Exposed Individuals Is Associated with Diminished Natural Cytotoxicity and Enhanced Antibody-Dependent Cellular Cytotoxicity
    Host Response and Inflammation
    PD-1 Expression on NK Cells in Malaria-Exposed Individuals Is Associated with Diminished Natural Cytotoxicity and Enhanced Antibody-Dependent Cellular Cytotoxicity

    Natural killer (NK) cells are key effector cells of innate resistance capable of destroying tumors and virus-infected cells through cytotoxicity and rapid cytokine production. The control of NK cell responses is complex and only partially understood. PD-1 is an inhibitory receptor that regulates T cell function, but a role for PD-1 in regulating NK cell function is only beginning to emerge.

    Jacqueline Moebius, Rajan Guha, Mary Peterson, Kaveh Abdi, Jeff Skinner, Shanping Li, Gunjan Arora, Boubacar Traore, Sumati Rajagopalan, Eric O. Long, Peter D. Crompton
  • Open Access
    Preclinical Development and Assessment of Viral Vectors Expressing a Fusion Antigen of <span class="named-content genus-species" id="named-content-1">Plasmodium falciparum</span> LSA1 and LSAP2 for Efficacy against Liver-Stage Malaria
    Microbial Immunity and Vaccines
    Preclinical Development and Assessment of Viral Vectors Expressing a Fusion Antigen of Plasmodium falciparum LSA1 and LSAP2 for Efficacy against Liver-Stage Malaria

    Despite promising progress in malaria vaccine development in recent years, an efficacious subunit vaccine against Plasmodium falciparum remains to be licensed and deployed. Cell-mediated protection from liver-stage malaria relies on a sufficient number of antigen-specific T cells reaching the liver during the time that parasites are present. A single vaccine...

    Benedict R. Halbroth, Sarah Sebastian, Ahmed M. Salman, Marta Ulaszewska, Anita Gola, Rhea J. Longley, Chris J. Janse, Shahid M. Khan, Adrian V. S. Hill, Alexandra J. Spencer

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