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malaria

  • ZBTB7B (ThPOK) Is Required for Pathogenesis of Cerebral Malaria and Protection against Pulmonary Tuberculosis
    Host Response and Inflammation
    ZBTB7B (ThPOK) Is Required for Pathogenesis of Cerebral Malaria and Protection against Pulmonary Tuberculosis

    We used a genome-wide screen in N-ethyl-N-nitrosourea (ENU)-mutagenized mice to identify genes in which recessive loss-of-function mutations protect against pathological neuroinflammation. We identified an R367Q mutation in the ZBTB7B (ThPOK) protein in which homozygosity causes protection against experimental cerebral malaria (ECM) caused by infection with...

    James M. Kennedy, Anna Georges, Angelia V. Bassenden, Silvia M. Vidal, Albert M. Berghuis, Ichiro Taniuchi, Jacek Majewski, Mark Lathrop, Marcel A. Behr, David Langlais, Philippe Gros
  • Splenic Innate B1 B Cell Plasmablasts Produce Sustained Granulocyte-Macrophage Colony-Stimulating Factor and Interleukin-3 Cytokines during Murine Malaria Infections
    Host Response and Inflammation
    Splenic Innate B1 B Cell Plasmablasts Produce Sustained Granulocyte-Macrophage Colony-Stimulating Factor and Interleukin-3 Cytokines during Murine Malaria Infections

    The physiopathology of malaria, one of the most deadly human parasitic diseases worldwide, is complex, as it is a systemic disease involving multiple parasitic stages and hosts and leads to the activation of numerous immune cells and release of inflammatory mediators.

    Shu Shien Chin, Laurent Chorro, John Chan, Grégoire Lauvau
  • Antimalarial Activity of Human Group IIA Secreted Phospholipase A<sub>2</sub> in Relation to Enzymatic Hydrolysis of Oxidized Lipoproteins
    Molecular Pathogenesis
    Antimalarial Activity of Human Group IIA Secreted Phospholipase A2 in Relation to Enzymatic Hydrolysis of Oxidized Lipoproteins

    The level of human group IIA secreted phospholipase A2 (hGIIA sPLA2) is increased in the plasma of malaria patients, but its role is unknown. In parasite culture with normal plasma, hGIIA is inactive against Plasmodium falciparum, contrasting with hGIIF, hGV, and hGX sPLA2s, which readily hydrolyze plasma lipoproteins, release...

    Mélanie Dacheux, Véronique Sinou, Christine Payré, Louise Jeammet, Daniel Parzy, Philippe Grellier, Christiane Deregnaucourt, Gérard Lambeau
  • Open Access
    Acquisition of IgG to ICAM-1-Binding DBLβ Domains in the <span class="named-content genus-species" id="named-content-1">Plasmodium falciparum</span> Erythrocyte Membrane Protein 1 Antigen Family Varies between Groups A, B, and C
    Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    Acquisition of IgG to ICAM-1-Binding DBLβ Domains in the Plasmodium falciparum Erythrocyte Membrane Protein 1 Antigen Family Varies between Groups A, B, and C

    Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is an important malaria virulence factor. The protein family can be divided into clinically relevant subfamilies. ICAM-1-binding group A PfEMP1 proteins also bind endothelial protein C receptor and have been associated with cerebral malaria in children. IgG to these PfEMP1 proteins is acquired later in life...

    Rebecca W. Olsen, Gertrude Ecklu-Mensah, Anja Bengtsson, Michael F. Ofori, Kwadwo A. Kusi, Kwadwo A. Koram, Lars Hviid, Yvonne Adams, Anja T. R. Jensen
  • Antibody-Dependent, Gamma Interferon-Independent Sterilizing Immunity Induced by a Subunit Malaria Vaccine
    Microbial Immunity and Vaccines
    Antibody-Dependent, Gamma Interferon-Independent Sterilizing Immunity Induced by a Subunit Malaria Vaccine

    The development of effective malaria vaccines is hampered by incomplete understanding of the immunological correlates of protective immunity. Recently, the moderate clinical efficacy of the Plasmodium falciparum circumsporozoite protein (CSP)-based RTS,S/AS01E vaccine in phase 3 studies highlighted the urgency to design and test more efficacious next-...

    Bhavna Chawla, Babita Mahajan, Miranda Oakley, Victoria F. Majam, Arnel Belmonte, Martha Sedegah, Richard L. Shimp, David C. Kaslow, Sanjai Kumar
  • <em>Anopheles gambiae</em> Lacking <em>AgTRIO</em> Inefficiently Transmits <em>Plasmodium berghei</em> to Mice
    Fungal and Parasitic Infections
    Anopheles gambiae Lacking AgTRIO Inefficiently Transmits Plasmodium berghei to Mice

    Antibodies to AgTRIO, a mosquito salivary protein, partially reduce the initial Plasmodium burden in mice. We therefore silenced AgTRIO in mosquitoes and determined the relative contribution of AgTRIO to the ability of Anopheles gambiae to transmit Plasmodium berghei to mice. RNA...

    Yu-Min Chuang, Marianna Freudzon, Jing Yang, Yuemei Dong, George Dimopoulos, Erol Fikrig
  • Functional Antibodies against Placental Malaria Parasites Are Variant Dependent and Differ by Geographic Region
    Microbial Immunity and Vaccines
    Functional Antibodies against Placental Malaria Parasites Are Variant Dependent and Differ by Geographic Region

    During pregnancy, Plasmodium falciparum-infected erythrocytes (IE) accumulate in the intervillous spaces of the placenta by binding to chondroitin sulfate A (CSA) and elicit inflammatory responses that are associated with poor pregnancy outcomes. Primigravidae lack immunity to IE that sequester in the placenta and thus are susceptible to placental malaria (PM).

    ...
    Justin Doritchamou, Andrew Teo, Robert Morrison, Gunjan Arora, Jennifer Kwan, Javier Manzella-Lapeira, Sarimar Medina-Maldonado, Jean Langhorne, Lars Hviid, David L. Narum, Alassane Dicko, Michal Fried, Patrick E. Duffy
  • Transmission-Blocking Vaccines: Old Friends and New Prospects
    Minireview
    Transmission-Blocking Vaccines: Old Friends and New Prospects

    In the progression of the life cycle of Plasmodium falciparum, a small proportion of asexual parasites differentiate into male or female sexual forms called gametocytes. Just like their asexual counterparts, gametocytes are contained within the infected host’s erythrocytes (RBCs).

    Festus K. Acquah, Joshua Adjah, Kim C. Williamson, Linda E. Amoah
  • Combining Monophosphoryl Lipid A (MPL), CpG Oligodeoxynucleotide (ODN), and QS-21 Adjuvants Induces Strong and Persistent Functional Antibodies and T Cell Responses against Cell-Traversal Protein for Ookinetes and Sporozoites (CelTOS) of <span class="named-content genus-species" id="named-content-1">Plasmodium falciparum</span> in BALB/c Mice
    Fungal and Parasitic Infections
    Combining Monophosphoryl Lipid A (MPL), CpG Oligodeoxynucleotide (ODN), and QS-21 Adjuvants Induces Strong and Persistent Functional Antibodies and T Cell Responses against Cell-Traversal Protein for Ookinetes and Sporozoites (CelTOS) of Plasmodium falciparum in BALB/c Mice

    Plasmodium falciparum cell-traversal protein for ookinetes and sporozoites (PfCelTOS) is an advanced vaccine candidate that has a crucial role in the traversal of the malaria parasite in both mosquito and mammalian hosts. As recombinant purified proteins are normally poor immunogens, they require to be admixed with an adjuvant(s); therefore, the objective of the...

    Sakineh Pirahmadi, Sedigheh Zakeri, Akram A. Mehrizi, Navid D. Djadid, Abbas-Ali Raz, Jafar J. Sani
  • Moderately Neutralizing Epitopes in Nonfunctional Regions Dominate the Antibody Response to <em>Plasmodium falciparum</em> EBA-140
    Microbial Immunity and Vaccines
    Moderately Neutralizing Epitopes in Nonfunctional Regions Dominate the Antibody Response to Plasmodium falciparum EBA-140

    Plasmodium falciparum erythrocyte-binding antigen 140 (EBA-140) plays a role in tight junction formation during parasite invasion of red blood cells and is a potential vaccine candidate for malaria. Individuals in areas where malaria is endemic possess EBA-140-specific antibodies, and individuals with high antibody titers to this protein have a lower rate of...

    Nichole D. Salinas, May M. Paing, Jagat Adhikari, Michael L. Gross, Niraj Tolia

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