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Infection and Immunity
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MyD88

  • Modification of the Pulmonary MyD88 Inflammatory Response Underlies the Role of the <span class="named-content genus-species" id="named-content-1">Yersinia pestis</span> Pigmentation Locus in Primary Pneumonic Plague
    Host Response and Inflammation
    Modification of the Pulmonary MyD88 Inflammatory Response Underlies the Role of the Yersinia pestis Pigmentation Locus in Primary Pneumonic Plague

    Pneumonic plague, caused by Yersinia pestis, is a rapidly progressing bronchopneumonia involving focal bacterial growth, neutrophilic congestion, and alveolar necrosis. Within a short time after inhalation of Y. pestis, inflammatory cytokines are expressed via the Toll/interleukin-1 (IL-1) adaptor...

    Rachel M. Olson, Miqdad O. Dhariwala, William J. Mitchell, Jerod A. Skyberg, Deborah M. Anderson
  • Immediate Interferon Gamma Induction Determines Murine Host Compatibility Differences between <span class="named-content genus-species" id="named-content-1">Toxoplasma gondii</span> and <span class="named-content genus-species" id="named-content-2">Neospora caninum</span>
    Molecular Pathogenesis
    Immediate Interferon Gamma Induction Determines Murine Host Compatibility Differences between Toxoplasma gondii and Neospora caninum

    Rodents are critical for the transmission of Toxoplasma gondii to the definitive feline host via predation, and this relationship has been extensively studied as a model for immune responses to parasites. Neospora caninum is a closely related coccidian parasite of ruminants and canines but is not...

    Rachel S. Coombs, Matthew L. Blank, Elizabeth D. English, Yaw Adomako-Ankomah, Ifeanyi-Chukwu Samuel Urama, Andrew T. Martin, Felix Yarovinsky, Jon P. Boyle
  • Open Access
    <span class="named-content genus-species" id="named-content-1">Yersinia pestis</span> Exploits Early Activation of MyD88 for Growth in the Lungs during Pneumonic Plague
    Host Response and Inflammation
    Yersinia pestis Exploits Early Activation of MyD88 for Growth in the Lungs during Pneumonic Plague

    Yersinia pestis causes bubonic, pneumonic, and septicemic plague. Although no longer responsible for pandemic outbreaks, pneumonic plague continues to be a challenge for medical treatment and has been classified as a reemerging disease in some parts of the world.

    Rachel M. Olson, Miqdad O. Dhariwala, William J. Mitchell, Deborah M. Anderson
  • Fungal and Parasitic Infections | Spotlight
    Myeloid Differentiation Factor 88 and Interleukin-1R1 Signaling Contribute to Resistance to Coccidioides immitis
    Suganya Viriyakosol, Lorraine Walls, Sharon Okamoto, Eyal Raz, David L. Williams, Joshua Fierer
  • Microbial Immunity and Vaccines
    MyD88 Signaling in T Cells Is Critical for Effector CD4 T Cell Differentiation following a Transitional T Follicular Helper Cell Stage
    Rajakumar Mandraju, Aakanksha Jain, Yajing Gao, Zhiming Ouyang, Michael V. Norgard, Chandrashekhar Pasare
  • Open Access
    Host Response and Inflammation
    Induction of Type I Interferon through a Noncanonical Toll-Like Receptor 7 Pathway during Yersinia pestis Infection
    Miqdad O. Dhariwala, Rachel M. Olson, Deborah M. Anderson
  • Host Response and Inflammation
    Temporal Role for MyD88 in a Model of Brucella-Induced Arthritis and Musculoskeletal Inflammation
    Carolyn A. Lacey, William J. Mitchell, Charles R. Brown, Jerod A. Skyberg
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