neutrophil
Molecular PathogenesisTissue Tropism in Streptococcal Infection: Wild-Type M1T1 Group A Streptococcus Is Efficiently Cleared by Neutrophils Using an NADPH Oxidase-Dependent Mechanism in the Lung but Not in the SkinGroup A Streptococcus (GAS) commonly causes pharyngitis and skin infections. Little is known why streptococcal pharyngitis usually does not lead to pneumonia and why the skin is a favorite niche for GAS. To partially address these questions, the effectiveness of neutrophils in clearing wild-type (wt) M1T1 GAS strain MGAS2221 from the lung and from the skin was examined in murine models of intratracheal pneumonia and...
Cellular Microbiology: Pathogen-Host Cell Molecular InteractionsNovel Assay To Characterize Neutrophil Responses to Oral BiofilmsNeutrophils, the most numerous leukocytes, play an important role in maintaining oral health through interactions with oral microbial biofilms. Both neutrophil hyperactivity and the bacterial subversion of neutrophil responses can cause inflammation-mediated tissue damage like that seen in periodontal disease.
- Cellular Microbiology: Pathogen-Host Cell Molecular InteractionsPeptoanaerobacter stomatis Primes Human Neutrophils and Induces Granule Exocytosis