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Infection and Immunity
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oxidative stress

  • STAT3 Promotes Schistosome-Induced Liver Injury by Inflammation, Oxidative Stress, Proliferation, and Apoptosis Signal Pathway
    Fungal and Parasitic Infections
    STAT3 Promotes Schistosome-Induced Liver Injury by Inflammation, Oxidative Stress, Proliferation, and Apoptosis Signal Pathway

    Schistosomiasis is a parasitic helminth disease that can cause organ lesions leading to health damage. During a schistosome infection, schistosome eggs can flow into the liver along the portal vein.

    Jie Zhao, Xin Liu, Yao Chen, Lin-Shuang Zhang, Ya-Rong Zhang, Deng-Ren Ji, Shi-Meng Liu, Mo-Zhi Jia, Yong-Hong Zhu, Yong-Fen Qi, Feng-Min Lu, Yan-Rong Yu
  • Bacterial Defense Systems against the Neutrophilic Oxidant Hypochlorous Acid
    Minireview
    Bacterial Defense Systems against the Neutrophilic Oxidant Hypochlorous Acid

    Neutrophils kill invading microbes and therefore represent the first line of defense of the innate immune response. Activated neutrophils assemble NADPH oxidase to convert substantial amounts of molecular oxygen into superoxide, which, after dismutation into peroxide, serves as the substrate for the generation of the potent antimicrobial hypochlorous acid (HOCl) in the phagosomal space. In this minireview, we explore the most recent...

    Sadia Sultana, Alessandro Foti, Jan-Ulrik Dahl
  • Open Access
    Molecular Pathogenesis
    Cyclo-(l-Phe-l-Pro), a Quorum-Sensing Signal of Vibrio vulnificus, Induces Expression of Hydroperoxidase through a ToxR-LeuO-HU-RpoS Signaling Pathway To Confer Resistance against Oxidative Stress

    Vibrio vulnificus, an opportunistic human pathogen, produces cyclo-(l-Phe-l-Pro) (cFP), which serves as a signaling molecule controlling the ToxR-dependent expression of innate bacterial genes, and also as a virulence factor eliciting pathogenic effects on human cells by enhancing intracellular reactive oxygen species...

    In Hwang Kim, So-Yeon Kim, Na-Young Park, Yancheng Wen, Keun-Woo Lee, So-Young Yoon, Haneul Jie, Kyu-Ho Lee, Kun-Soo Kim
  • Open Access
    Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    Diaphorina citri Nymphs Are Resistant to Morphological Changes Induced by “Candidatus Liberibacter asiaticus” in Midgut Epithelial Cells
    Marina Mann, Somayeh Fattah-Hosseini, El-Desouky Ammar, Richard Stange, EricaRose Warrick, Kasie Sturgeon, Robert Shatters, Michelle Heck
  • Free
    Molecular Pathogenesis | Spotlight
    Cell Invasion and Pyruvate Oxidase-Derived H2O2 Are Critical for Streptococcus pneumoniae-Mediated Cardiomyocyte Killing
    Terry Brissac, Anukul T. Shenoy, LaDonna A. Patterson, Carlos J. Orihuela
  • Fungal and Parasitic Infections
    Inherent Oxidative Stress in the Lewis Rat Is Associated with Resistance to Toxoplasmosis
    William H. Witola, Chi Yong Kim, Xuejin Zhang
  • Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    Pseudomonas Quinolone Signal Induces Oxidative Stress and Inhibits Heme Oxygenase-1 Expression in Lung Epithelial Cells
    Maher Y. Abdalla, Traci Hoke, Javier Seravalli, Barbara L. Switzer, Melissa Bavitz, Jill D. Fliege, Peter J. Murphy, Bradley E. Britigan
  • Molecular Genomics
    Global Transcriptional Response to Organic Hydroperoxide and the Role of OhrR in the Control of Virulence Traits in Chromobacterium violaceum
    Maristela Previato-Mello, Diogo de Abreu Meireles, Luis Eduardo Soares Netto, José Freire da Silva Neto
  • Molecular Pathogenesis
    Association of Metal Homeostasis and (p)ppGpp Regulation in the Pathophysiology of Enterococcus faecalis
    C. Colomer-Winter, A. O. Gaca, J. A. Lemos
  • Free
    Bacterial Infections | Spotlight
    The PerR-Regulated P1B-4-Type ATPase (PmtA) Acts as a Ferrous Iron Efflux Pump in Streptococcus pyogenes
    Andrew G. Turner, Cheryl-lynn Y. Ong, Karrera Y. Djoko, Nicholas P. West, Mark R. Davies, Alastair G. McEwan, Mark J. Walker

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