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Infection and Immunity
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parasite

  • Importance of the Immunodominant CD8<sup>+</sup> T Cell Epitope of <span class="named-content genus-species" id="named-content-1">Plasmodium berghei</span> Circumsporozoite Protein in Parasite- and Vaccine-Induced Protection
    Fungal and Parasitic Infections
    Importance of the Immunodominant CD8+ T Cell Epitope of Plasmodium berghei Circumsporozoite Protein in Parasite- and Vaccine-Induced Protection

    The circumsporozoite protein (CSP) builds up the surface coat of sporozoites and is the leading malaria pre-erythrocytic-stage vaccine candidate. CSP has been shown to induce robust CD8+ T cell responses that are capable of eliminating developing parasites in hepatocytes, resulting in protective immunity. In this study, we characterized the importance of the immunodominant CSP-derived epitope SYIPSAEKI of...

    Matthew P. Gibbins, Katja Müller, Maya Glover, Jasmine Liu, Elyzana D. Putrianti, Karolis Bauza, Arturo Reyes-Sandoval, Kai Matuschewski, Olivier Silvie, Julius Clemence R. Hafalla
  • Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    Plasmodium falciparum MSP3 Exists in a Complex on the Merozoite Surface and Generates Antibody Response during Natural Infection

    Plasmodium falciparum merozoite surface protein 3 (MSP3) is an abundantly expressed secreted merozoite surface protein and a leading malaria vaccine candidate antigen. However, it is unclear how MSP3 is retained on the surface of merozoites without a glycosylphosphatidylinositol (GPI) anchor or a transmembrane domain.

    Arunaditya Deshmukh, Bishwanath Kumar Chourasia, Sonali Mehrotra, Ikhlaq Hussain Kana, Gourab Paul, Ashutosh Panda, Inderjeet Kaur, Susheel Kumar Singh, Sumit Rathore, Aparup Das, Priya Gupta, Md Kalamuddin, S. K. Gakhar, Asif Mohmmed, Michael Theisen, Pawan Malhotra
  • Microbial Immunity and Vaccines
    Oral Application of Recombinant Bacillus subtilis Spores to Dogs Results in a Humoral Response against Specific Echinococcus granulosus Paramyosin and Tropomyosin Antigens
    Cédric M. Vogt, Maria Teresa Armúa-Fernández, Kurt Tobler, Monika Hilbe, Claudio Aguilar, Mathias Ackermann, Peter Deplazes, Catherine Eichwald
  • Open Access
    Minireview
    Parasitic Protozoa and Interactions with the Host Intestinal Microbiota
    Stacey L. Burgess, Carol A. Gilchrist, Tucker C. Lynn, William A. Petri
  • Fungal and Parasitic Infections
    Giardia Alters Commensal Microbial Diversity throughout the Murine Gut
    N. R. Barash, J. G. Maloney, S. M. Singer, S. C. Dawson
  • Open Access
    Microbial Immunity and Vaccines
    The Plasmodium falciparum Cell-Traversal Protein for Ookinetes and Sporozoites as a Candidate for Preerythrocytic and Transmission-Blocking Vaccines
    Diego A. Espinosa, Joel Vega-Rodriguez, Yevel Flores-Garcia, Amy R. Noe, Christian Muñoz, Russell Coleman, Torben Bruck, Keith Haney, Alex Stevens, Diane Retallack, Jeff Allen, Thomas S. Vedvick, Christopher B. Fox, Steven G. Reed, Randall F. Howard, Ahmed M. Salman, Chris J. Janse, Shahid M. Khan, Fidel Zavala, Gabriel M. Gutierrez
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