periodontitis
Host-Associated Microbial CommunitiesMicrobiome Profiles of Ligature-Induced Periodontitis in Nonhuman Primates across the Life SpanThis investigation compared the microbiomes colonizing teeth during the initiation, progression, and resolution of periodontitis in nonhuman primates (Macaca mulatta) at different ages. Subgingival plaque samples were collected at baseline; 0.5, 1, and 3 months following ligature-induced periodontitis; and following naturally occurring disease resolution at 5 months...
Bacterial InfectionsThe Porphyromonas gingivalis Hybrid Cluster Protein Hcp Is Required for Growth with Nitrite and Survival with Host CellsAlthough the periodontal pathogen Porphyromonas gingivalis must withstand high levels of nitrosative stress while in the oral cavity, the mechanisms of nitrosative stress defense are not well understood in this organism. Previously we showed that the transcriptional regulator HcpR plays a significant role in defense, and here we further defined its regulon.
...
Cellular Microbiology: Pathogen-Host Cell Molecular InteractionsA Nonfimbrial Adhesin of Aggregatibacter actinomycetemcomitans Mediates Biofilm BiogenesisPeriodontitis is an inflammatory disease caused by polymicrobial biofilms. The periodontal pathogen Aggregatibacter actinomycetemcomitans displays two proteinaceous surface structures, the fimbriae and the nonfimbrial extracellular matrix binding protein A (EmaA), as observed by electron microscopy.
- Host Response and InflammationReduction of Articular and Systemic Inflammation by Kava-241 in a Porphyromonas gingivalis-Induced Arthritis Murine Model
Rheumatoid arthritis (RA) is an inflammatory disease that has been linked to several risk factors, including periodontitis. Identification of new anti-inflammatory compounds to treat arthritis is needed.
- Cellular Microbiology: Pathogen-Host Cell Molecular InteractionsModulation of Neutrophil Extracellular Trap and Reactive Oxygen Species Release by Periodontal Bacteria
- Host Response and InflammationB10 Cells Alleviate Periodontal Bone Loss in Experimental Periodontitis
- Cellular Microbiology: Pathogen-Host Cell Molecular InteractionsPeptoanaerobacter stomatis Primes Human Neutrophils and Induces Granule Exocytosis