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Infection and Immunity
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PfEMP1

  • Open Access
    Acquisition of IgG to ICAM-1-Binding DBLβ Domains in the <span class="named-content genus-species" id="named-content-1">Plasmodium falciparum</span> Erythrocyte Membrane Protein 1 Antigen Family Varies between Groups A, B, and C
    Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    Acquisition of IgG to ICAM-1-Binding DBLβ Domains in the Plasmodium falciparum Erythrocyte Membrane Protein 1 Antigen Family Varies between Groups A, B, and C

    Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is an important malaria virulence factor. The protein family can be divided into clinically relevant subfamilies. ICAM-1-binding group A PfEMP1 proteins also bind endothelial protein C receptor and have been associated with cerebral malaria in children. IgG to these PfEMP1 proteins is acquired later in life...

    Rebecca W. Olsen, Gertrude Ecklu-Mensah, Anja Bengtsson, Michael F. Ofori, Kwadwo A. Kusi, Kwadwo A. Koram, Lars Hviid, Yvonne Adams, Anja T. R. Jensen
  • Immunization with Recombinant <span class="named-content genus-species" id="named-content-1">Plasmodium falciparum</span> Erythrocyte Membrane Protein 1 CIDRα1 Domains Induces Domain Subtype Inhibitory Antibodies
    Microbial Immunity and Vaccines
    Immunization with Recombinant Plasmodium falciparum Erythrocyte Membrane Protein 1 CIDRα1 Domains Induces Domain Subtype Inhibitory Antibodies

    Plasmodium falciparum malaria pathogenesis is tied to the sequestration of parasites in the microvasculature. Parasite sequestration leading to severe malaria is mediated by P. falciparum erythrocyte membrane protein 1 (PfEMP1) binding to endothelial protein C receptor (EPCR) via its CIDRα1 domains...

    Louise Turner, Thor G. Theander, Thomas Lavstsen
  • Microbial Immunity and Vaccines
    Antibodies to Intercellular Adhesion Molecule 1-Binding Plasmodium falciparum Erythrocyte Membrane Protein 1-DBLβ Are Biomarkers of Protective Immunity to Malaria in a Cohort of Young Children from Papua New Guinea

    Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) mediates parasite sequestration to the cerebral microvasculature via binding of DBLβ domains to intercellular adhesion molecule 1 (ICAM1) and is associated with severe cerebral malaria. In a cohort of 187 young children from Papua New Guinea (PNG), we examined baseline levels of antibody to the ICAM1-...

    Sofonias K. Tessema, Digjaya Utama, Olga Chesnokov, Anthony N. Hodder, Clara S. Lin, G. L. Abby Harrison, Jakob S. Jespersen, Bent Petersen, Livingstone Tavul, Peter Siba, Dominic Kwiatkowski, Thomas Lavstsen, Diana S. Hansen, Andrew V. Oleinikov, Ivo Mueller, Alyssa E. Barry
  • Open Access
    Fungal and Parasitic Infections
    IgG Responses to the Plasmodium falciparum Antigen VAR2CSA in Colombia Are Restricted to Pregnancy and Are Not Induced by Exposure to Plasmodium vivax

    Clinical immunity to malaria is associated with the acquisition of IgG specific for members of the Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family of clonally variant antigens on the surface of infected erythrocytes (IEs). The VAR2CSA subtype of PfEMP1 mediates IE binding in the placenta.

    Mary Lopez-Perez, Mads Delbo Larsen, Rafael Bayarri-Olmos, Paulina Ampomah, Liz Stevenson, Myriam Arévalo-Herrera, Sócrates Herrera, Lars Hviid
  • Open Access
    Host Response and Inflammation
    Natural and Vaccine-Induced Acquisition of Cross-Reactive IgG-Inhibiting ICAM-1-Specific Binding of a Plasmodium falciparum PfEMP1 Subtype Associated Specifically with Cerebral Malaria
    Rebecca W. Olsen, Gertrude Ecklu-Mensah, Anja Bengtsson, Michael F. Ofori, John P. A. Lusingu, Filip C. Castberg, Lars Hviid, Yvonne Adams, Anja T. R. Jensen
  • Open Access
    Microbial Immunity and Vaccines
    Plasmodium falciparum PfEMP1 Modulates Monocyte/Macrophage Transcription Factor Activation and Cytokine and Chemokine Responses
    Natália Guimarães Sampaio, Emily Marie Eriksson, Louis Schofield
  • Free
    Cellular Microbiology: Pathogen-Host Cell Molecular Interactions | Spotlight
    The Severity of Plasmodium falciparum Infection Is Associated with Transcript Levels of var Genes Encoding Endothelial Protein C Receptor-Binding P. falciparum Erythrocyte Membrane Protein 1
    Sixbert I. Mkumbaye, Christian W. Wang, Eric Lyimo, Jakob S. Jespersen, Alphaxard Manjurano, Jacklin Mosha, Reginald A. Kavishe, Steven B. Mwakalinga, Daniel T. R. Minja, John P. Lusingu, Thor G. Theander, Thomas Lavstsen
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