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phase variation

  • Slipped-Strand Mispairing in the Gene Encoding Sialidase NanH3 in <em>Gardnerella</em> spp.
    Host-Associated Microbial Communities
    Slipped-Strand Mispairing in the Gene Encoding Sialidase NanH3 in Gardnerella spp.

    Cell wall proteins with sialidase activity are involved in carbohydrate assimilation, adhesion to mucosal surfaces, and biofilm formation. Gardnerella spp. inhabit the human vaginal microbiome and encode up to three sialidase enzymes, two of which are suspected to be cell wall associated. Here, we demonstrate that the gene encoding extracellular sialidase NanH3 is found almost exclusively in...

    Shakya P. Kurukulasuriya, Mo H. Patterson, Janet E. Hill
  • Evaluation of the Protective Ability of the <span class="named-content genus-species" id="named-content-1">Treponema pallidum</span> subsp. <em>pallidum</em> Tp0126 OmpW Homolog in the Rabbit Model of Syphilis
    Microbial Immunity and Vaccines
    Evaluation of the Protective Ability of the Treponema pallidum subsp. pallidum Tp0126 OmpW Homolog in the Rabbit Model of Syphilis

    In silico analyses of Treponema pallidum subsp. pallidum genomes and predicted proteomes to search for homologs of known bacterial outer membrane proteins (OMPs) led to the identification of tp0126 as a gene encoding a putative member of the OmpW family of porins/virulence factors. Our previous investigations on the role of Tp0126 in...

    Austin M. Haynes, Charmie Godornes, Wujian Ke, Lorenzo Giacani
  • Open Access
    Analysis of Invasive Nontypeable <em>Haemophilus influenzae</em> Isolates Reveals Selection for the Expression State of Particular Phase-Variable Lipooligosaccharide Biosynthetic Genes
    Molecular Pathogenesis
    Analysis of Invasive Nontypeable Haemophilus influenzae Isolates Reveals Selection for the Expression State of Particular Phase-Variable Lipooligosaccharide Biosynthetic Genes

    Nontypeable Haemophilus influenzae (NTHi) is a major human pathogen, responsible for several acute and chronic infections of the respiratory tract. The incidence of invasive infections caused by NTHi is increasing worldwide.

    Zachary N. Phillips, Charles Brizuela, Amy V. Jennison, Megan Staples, Keith Grimwood, Kate L. Seib, Michael P. Jennings, John M. Atack
  • Molecular Pathogenesis
    Mycoplasma genitalium Nonadherent Phase Variants Arise by Multiple Mechanisms and Escape Antibody-Dependent Growth Inhibition
    Raul Burgos, Gwendolyn E. Wood, Stefanie L. Iverson-Cabral, Patricia A. Totten
  • Molecular Pathogenesis
    Phasevarion-Regulated Virulence in the Emerging Pediatric Pathogen Kingella kingae
    Yogitha N. Srikhanta, Ka Yee Fung, Georgina L. Pollock, Vicki Bennett-Wood, Benjamin P. Howden, Elizabeth L. Hartland
  • Open Access
    Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    Salmonella enterica Serovar Typhi Lipopolysaccharide O-Antigen Modification Impact on Serum Resistance and Antibody Recognition
    Erica Kintz, Christian Heiss, Ian Black, Nicholas Donohue, Naj Brown, Mark R. Davies, Parastoo Azadi, Stephen Baker, Paul M. Kaye, Marjan van der Woude
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