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Infection and Immunity
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protection

  • Importance of the Immunodominant CD8<sup>+</sup> T Cell Epitope of <span class="named-content genus-species" id="named-content-1">Plasmodium berghei</span> Circumsporozoite Protein in Parasite- and Vaccine-Induced Protection
    Fungal and Parasitic Infections
    Importance of the Immunodominant CD8+ T Cell Epitope of Plasmodium berghei Circumsporozoite Protein in Parasite- and Vaccine-Induced Protection

    The circumsporozoite protein (CSP) builds up the surface coat of sporozoites and is the leading malaria pre-erythrocytic-stage vaccine candidate. CSP has been shown to induce robust CD8+ T cell responses that are capable of eliminating developing parasites in hepatocytes, resulting in protective immunity. In this study, we characterized the importance of the immunodominant CSP-derived epitope SYIPSAEKI of...

    Matthew P. Gibbins, Katja Müller, Maya Glover, Jasmine Liu, Elyzana D. Putrianti, Karolis Bauza, Arturo Reyes-Sandoval, Kai Matuschewski, Olivier Silvie, Julius Clemence R. Hafalla
  • Towards Innovative Design and Application of Recombinant <em>Eimeria</em> as a Vaccine Vector
    Minireview
    Towards Innovative Design and Application of Recombinant Eimeria as a Vaccine Vector

    Efficient delivery of antigenic cargo to trigger protective immune responses is critical to the success of vaccination. Genetically engineered microorganisms, including virus, bacteria, and protozoa, can be modified to carry and deliver heterologous antigens to the host immune system. The biological vectors can induce a broad range of immune responses and enhance heterologous antigen-specific immunological outcomes. The protozoan genus...

    Xinming Tang, Xianyong Liu, Xun Suo
  • Unbiased Identification of Immunogenic <span class="named-content genus-species" id="named-content-1">Staphylococcus aureus</span> Leukotoxin B-Cell Epitopes
    Microbial Immunity and Vaccines
    Unbiased Identification of Immunogenic Staphylococcus aureus Leukotoxin B-Cell Epitopes

    Unbiased identification of individual immunogenic B-cell epitopes in major antigens of a pathogen remains a technology challenge for vaccine discovery. We therefore developed a platform for rapid phage display screening of deep recombinant libraries consisting of as few as one major pathogen antigen. Using the bicomponent pore-forming leukocidin (Luk) exotoxins of the major pathogen...

    David N. Hernandez, Kayan Tam, Bo Shopsin, Emily E. Radke, Pegah Kolahi, Richard Copin, François-Xavier Stubbe, Timothy Cardozo, Victor J. Torres, Gregg J. Silverman
  • Antibody-Dependent, Gamma Interferon-Independent Sterilizing Immunity Induced by a Subunit Malaria Vaccine
    Microbial Immunity and Vaccines
    Antibody-Dependent, Gamma Interferon-Independent Sterilizing Immunity Induced by a Subunit Malaria Vaccine

    The development of effective malaria vaccines is hampered by incomplete understanding of the immunological correlates of protective immunity. Recently, the moderate clinical efficacy of the Plasmodium falciparum circumsporozoite protein (CSP)-based RTS,S/AS01E vaccine in phase 3 studies highlighted the urgency to design and test more efficacious next-...

    Bhavna Chawla, Babita Mahajan, Miranda Oakley, Victoria F. Majam, Arnel Belmonte, Martha Sedegah, Richard L. Shimp, David C. Kaslow, Sanjai Kumar
  • Delineating Surface Epitopes of Lyme Disease Pathogen Targeted by Highly Protective Antibodies of New Zealand White Rabbits
    Microbial Immunity and Vaccines
    Delineating Surface Epitopes of Lyme Disease Pathogen Targeted by Highly Protective Antibodies of New Zealand White Rabbits

    Lyme disease (LD), the most prevalent vector-borne illness in the United States and Europe, is caused by Borreliella burgdorferi. No vaccine is available for humans. Dogmatically, B. burgdorferi can establish a persistent infection in the mammalian host (e.g., mice) due to a surface antigen, VlsE....

    Artem S. Rogovskyy, Salvador Eugenio C. Caoili, Yurij Ionov, Helen Piontkivska, Pavel Skums, Viachaslau Tsyvina, Alex Zelikovsky, Suryakant D. Waghela
  • Microbial Immunity and Vaccines
    Identification of Surface Epitopes Associated with Protection against Highly Immune-Evasive VlsE-Expressing Lyme Disease Spirochetes

    The tick-borne pathogen Borrelia burgdorferi is responsible for approximately 300,000 Lyme disease (LD) cases per year in the United States. Recent increases in the number of LD cases, in addition to the spread of the tick vector and a lack of a vaccine, highlight an urgent need for designing and developing an efficacious LD vaccine.

    Maliha Batool, Salvador Eugenio C. Caoili, Lawrence J. Dangott, Ekaterina Gerasimov, Yurij Ionov, Helen Piontkivska, Alex Zelikovsky, Suryakant D. Waghela, Artem S. Rogovskyy
  • Open Access
    Bacterial Infections
    Clostridium difficile Toxoid Vaccine Candidate Confers Broad Protection against a Range of Prevalent Circulating Strains in a Nonclinical Setting
    Laurence Quemeneur, Nadine Petiot, Nadège Arnaud-Barbe, Catherine Hessler, Patricia J. Pietrobon, Patricia Londoño-Hayes
  • Microbial Immunity and Vaccines
    A Plasmodium Parasite with Complete Late Liver Stage Arrest Protects against Preerythrocytic and Erythrocytic Stage Infection in Mice
    Ashley M. Vaughan, Brandon K. Sack, Dorender Dankwa, Nana Minkah, Thao Nguyen, Hayley Cardamone, Stefan H. I. Kappe
  • Open Access
    Microbial Immunity and Vaccines | Spotlight
    Development of Subunit Vaccines That Provide High-Level Protection and Sterilizing Immunity against Acute Inhalational Melioidosis
    Mary N. Burtnick, Teresa L. Shaffer, Brittany N. Ross, Laura A. Muruato, Elena Sbrana, David DeShazer, Alfredo G. Torres, Paul J. Brett
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