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Infection and Immunity
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RNA-Seq

  • Interleukin-8 Receptor 2 (IL-8R2)-Deficient Mice Are More Resistant to Pulmonary Coccidioidomycosis than Control Mice
    Fungal and Parasitic Infections
    Interleukin-8 Receptor 2 (IL-8R2)-Deficient Mice Are More Resistant to Pulmonary Coccidioidomycosis than Control Mice

    The pathology of human coccidioidomycosis is granulomatous inflammation with many neutrophils surrounding ruptured spherules, but the chemotactic pathways that draw neutrophils into the infected tissues are not known. We previously showed that formalin-killed spherules (FKS) stimulate mouse macrophages to secret macrophage inflammatory protein 2 (MIP-2), which suggested that CXC ELR+ chemokines might be involved in neutrophil...

    Aaron F. Carlin, Suganya Viriyakosol, Sharon Okamoto, Lorraine Walls, Joshua Fierer
  • Differential Response of the Chicken Trachea to Chronic Infection with Virulent <span class="named-content genus-species" id="named-content-1">Mycoplasma gallisepticum</span> Strain Ap3AS and Vaxsafe MG (Strain ts-304): a Transcriptional Profile
    Host Response and Inflammation
    Differential Response of the Chicken Trachea to Chronic Infection with Virulent Mycoplasma gallisepticum Strain Ap3AS and Vaxsafe MG (Strain ts-304): a Transcriptional Profile

    Mycoplasma gallisepticum is the primary etiological agent of chronic respiratory disease in chickens. Live attenuated vaccines are most commonly used in the field to control the disease, but current vaccines have some limitations. Vaxsafe MG (strain ts-304) is a new vaccine candidate that is efficacious at a lower dose than the current commercial vaccine strain ts-11...

    Sathya N. Kulappu Arachchige, Neil D. Young, Pollob K. Shil, Alistair R. Legione, Anna Kanci Condello, Glenn F. Browning, Nadeeka K. Wawegama
  • Transcriptional and Pathological Host Responses to Coinfection with Virulent or Attenuated <span class="named-content genus-species" id="named-content-1">Mycoplasma gallisepticum</span> and Low-Pathogenic Avian Influenza A Virus in Chickens
    Host Response and Inflammation
    Transcriptional and Pathological Host Responses to Coinfection with Virulent or Attenuated Mycoplasma gallisepticum and Low-Pathogenic Avian Influenza A Virus in Chickens

    The avian pathogen Mycoplasma gallisepticum, the etiological agent of chronic respiratory disease in chickens, exhibits enhanced pathogenesis in the presence of a copathogen such as low-pathogenic avian influenza virus (LPAIV).

    J. A. Canter, E. R. Tulman, J. Beaudet, D.-H. Lee, M. May, S. M. Szczepanek, S. J. Geary
  • Transcriptional Analysis Shows a Robust Host Response to <em>Toxoplasma gondii</em> during Early and Late Chronic Infection in Both Male and Female Mice
    Host Response and Inflammation | Spotlight
    Transcriptional Analysis Shows a Robust Host Response to Toxoplasma gondii during Early and Late Chronic Infection in Both Male and Female Mice

    The long-term host effects caused by the protozoan parasite Toxoplasma gondii are poorly understood. High-throughput RNA sequencing analysis previously determined that the host response in the brain was greater and more complex at 28 days than at 10 days postinfection.

    Andrew L. Garfoot, Patrick W. Cervantes, Laura J. Knoll
  • Variable Lipoprotein Hemagglutinin A Gene (<em>vlhA</em>) Expression in Variant <span class="named-content genus-species" id="named-content-1">Mycoplasma</span> <span class="named-content genus-species" id="named-content-2">gallisepticum</span> Strains <em>In Vivo</em>
    Molecular Pathogenesis
    Variable Lipoprotein Hemagglutinin A Gene (vlhA) Expression in Variant Mycoplasma gallisepticum Strains In Vivo

    Mycoplasma gallisepticum, the primary etiologic agent of chronic respiratory disease, is a significant poultry pathogen, causing severe inflammation and leading to economic losses worldwide. Immunodominant proteins encoded by the variable lipoprotein and hemagglutinin (vlhA) gene family are thought to be important for...

    K. Pflaum, E. R. Tulman, J. Beaudet, J. Canter, S. J. Geary
  • Host-Associated Microbial Communities
    A Vaginal Tract Signal Detected by the Group B Streptococcus SaeRS System Elicits Transcriptomic Changes and Enhances Murine Colonization
    Laura C. C. Cook, Hong Hu, Mark Maienschein-Cline, Michael J. Federle
  • Open Access
    Bacterial Infections
    Comparison of Salmonella enterica Serovars Typhi and Typhimurium Reveals Typhoidal Serovar-Specific Responses to Bile
    Rebecca Johnson, Matt Ravenhall, Derek Pickard, Gordon Dougan, Alexander Byrne, Gad Frankel
  • Molecular Pathogenesis
    Small RNA teg49 Is Derived from a sarA Transcript and Regulates Virulence Genes Independent of SarA in Staphylococcus aureus
    Adhar C. Manna, Samin Kim, Liviu Cengher, Anna Corvaglia, Stefano Leo, Patrice Francois, Ambrose L. Cheung
  • Host Response and Inflammation
    Transcriptional Profiling of the Chicken Tracheal Response to Virulent Mycoplasma gallisepticum Strain Rlow
    J. Beaudet, E. R. Tulman, K. Pflaum, X. Liao, G. F. Kutish, S. M. Szczepanek, L. K. Silbart, S. J. Geary
  • Molecular Pathogenesis
    Both MisR (CpxR) and MisS (CpxA) Are Required for Neisseria gonorrhoeae Infection in a Murine Model of Lower Genital Tract Infection
    Dharanesh Gangaiah, Erica L. Raterman, Hong Wu, Kate R. Fortney, Hongyu Gao, Yunlong Liu, Ann E. Jerse, Stanley M. Spinola
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