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Streptococcus

  • Group A Streptococcus AdcR Regulon Participates in Bacterial Defense against Host-Mediated Zinc Sequestration and Contributes to Virulence
    Bacterial Infections
    Group A Streptococcus AdcR Regulon Participates in Bacterial Defense against Host-Mediated Zinc Sequestration and Contributes to Virulence

    Colonization by pathogenic bacteria depends on their ability to overcome host nutritional defenses and acquire nutrients. The human pathogen group A streptococcus (GAS) encounters the host defense factor calprotectin (CP) during infection. CP inhibits GAS growth in vitro by imposing zinc (Zn) limitation. However, GAS counterstrategies to combat CP-mediated Zn limitation and the in vivo relevance of CP-GAS interactions...

    Nishanth Makthal, Hackwon Do, Brian M. Wendel, Randall J. Olsen, John D. Helmann, James M. Musser, Muthiah Kumaraswami
  • Genomic, Phenotypic, and Virulence Analysis of <em>Streptococcus sanguinis</em> Oral and Infective-Endocarditis Isolates
    Molecular Genomics
    Genomic, Phenotypic, and Virulence Analysis of Streptococcus sanguinis Oral and Infective-Endocarditis Isolates

    Streptococcus sanguinis, an abundant and benign inhabitant of the oral cavity, is an important etiologic agent of infective endocarditis (IE), particularly in people with predisposing cardiac valvular damage. Although commonly isolated from patients with IE, little is known about the factors that make any particular...

    Shannon P. Baker, Tara J. Nulton, Todd Kitten
  • Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    Serine-Rich Repeat Adhesins Mediate Shear-Enhanced Streptococcal Binding to Platelets
    Olga Yakovenko, Jamie Nunez, Barbara Bensing, Hai Yu, Jonathan Mount, Jie Zeng, Jasmine Hawkins, Xi Chen, Paul M. Sullam, Wendy Thomas
  • Molecular Genomics
    Characterization of the Pathogenicity of Streptococcus intermedius TYG1620 Isolated from a Human Brain Abscess Based on the Complete Genome Sequence with Transcriptome Analysis and Transposon Mutagenesis in a Murine Subcutaneous Abscess Model
    Noriko Hasegawa, Tsuyoshi Sekizuka, Yutaka Sugi, Nobuhiro Kawakami, Yumiko Ogasawara, Kengo Kato, Akifumi Yamashita, Fumihiko Takeuchi, Makoto Kuroda
  • Molecular Pathogenesis
    A Conserved C-Terminal 13-Amino-Acid Motif of Gap1 Is Required for Gap1 Function and Necessary for the Biogenesis of a Serine-Rich Glycoprotein of Streptococcus parasanguinis
    Meixian Zhou, Zhixiang Peng, Paula Fives-Taylor, Hui Wu
  • Host Response and Inflammation | Spotlight
    The Commensal Streptococcus salivarius K12 Downregulates the Innate Immune Responses of Human Epithelial Cells and Promotes Host-Microbe Homeostasis
    Celine Cosseau, Deirdre A. Devine, Edie Dullaghan, Jennifer L. Gardy, Avinash Chikatamarla, Shaan Gellatly, Lorraine L. Yu, Jelena Pistolic, Reza Falsafi, John Tagg, Robert E. W. Hancock
  • Bacterial Infections
    Population Diversity and Dynamics of Streptococcus mitis, Streptococcus oralis, and Streptococcus infantis in the Upper Respiratory Tracts of Adults, Determined by a Nonculture Strategy
    Malene Bek-Thomsen, Hervé Tettelin, Ioana Hance, Karen E. Nelson, Mogens Kilian
  • Microbial Immunity and Vaccines
    Role of d-Alanylation of Streptococcus gordonii Lipoteichoic Acid in Innate and Adaptive Immunity
    Karenn G. Chan, Matt Mayer, Elisabeth M. Davis, Scott A. Halperin, Tong-Jun Lin, Song F. Lee
  • Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    Gingival Epithelial Cell Transcriptional Responses to Commensal and Opportunistic Oral Microbial Species
    Yoshiaki Hasegawa, Jeffrey J. Mans, Song Mao, M. Cecilia Lopez, Henry V. Baker, Martin Handfield, Richard J. Lamont
  • Molecular Pathogenesis
    The Glycan Moieties and the N-Terminal Polypeptide Backbone of a Fimbria-Associated Adhesin, Fap1, Play Distinct Roles in the Biofilm Development of Streptococcus parasanguinis
    Hui Wu, Meiqin Zeng, Paula Fives-Taylor

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