Streptococcus agalactiae
Bacterial InfectionsThe Novel Streptococcal Transcriptional Regulator XtgS Negatively Regulates Bacterial Virulence and Directly Represses PseP TranscriptionStreptococcus agalactiae (group B streptococcus [GBS]) has received continuous attention for its involvement in invasive infections and its broad host range. Transcriptional regulators have an important impact on bacterial adaptation to various environments. Research on transcriptional regulators will shed new light on GBS pathogenesis. In this study, we identified a...
Bacterial InfectionsGenome-Wide Assessment of Streptococcus agalactiae Genes Required for Survival in Human Whole Blood and PlasmaStreptococcus agalactiae (group B streptococcus, or GBS) is a common cause of bacteremia and sepsis in newborns, pregnant women, and immunocompromised patients. The molecular mechanisms used by GBS to survive and proliferate in blood are not well understood. Here, using a highly virulent GBS strain and transposon-directed insertion site sequencing (TraDIS), we...
Cellular Microbiology: Pathogen-Host Cell Molecular InteractionsModulation of Death and Inflammatory Signaling in Decidual Stromal Cells following Exposure to Group B StreptococcusGroup B Streptococcus (GBS) is an opportunistic bacterial pathogen that contributes to miscarriage, preterm birth, and serious neonatal infections. Studies have indicated that some multilocus sequence types (STs) of GBS are more likely to cause severe disease than others. We hypothesized that the ability of GBS to elicit varying host responses in maternal decidual tissue during pregnancy is an important factor regulating...
- Host-Associated Microbial CommunitiesA Vaginal Tract Signal Detected by the Group B Streptococcus SaeRS System Elicits Transcriptomic Changes and Enhances Murine Colonization
- Molecular PathogenesisHuman Serum Induces Streptococcal C5a Peptidase Expression
- Host Response and InflammationRole of p38 and Early Growth Response Factor 1 in the Macrophage Response to Group B Streptococcus