Streptococcus agalactiae
Cellular Microbiology: Pathogen-Host Cell Molecular InteractionsDistinct Group B Streptococcus Sequence and Capsule Types Differentially Impact Macrophage Stress and Inflammatory Signaling ResponsesGroup B Streptococcus (GBS) is an opportunistic bacterial pathogen that can contribute to the induction of preterm birth in colonized pregnant women and to severe neonatal disease. Many questions regarding the mechanisms that drive GBS-associated pathogenesis remain unanswered, and it is not yet clear why virulence has been observed to vary so extensively across GBS strains.
MinireviewPolymicrobial Interactions in the Urinary Tract: Is the Enemy of My Enemy My Friend?The vast majority of research pertaining to urinary tract infection has focused on a single pathogen in isolation and predominantly Escherichia coli. However, polymicrobial urine colonization and infections are prevalent in several patient populations, including individuals with urinary catheters.
Bacterial InfectionsThe Novel Streptococcal Transcriptional Regulator XtgS Negatively Regulates Bacterial Virulence and Directly Represses PseP TranscriptionStreptococcus agalactiae (group B streptococcus [GBS]) has received continuous attention for its involvement in invasive infections and its broad host range. Transcriptional regulators have an important impact on bacterial adaptation to various environments. Research on transcriptional regulators will shed new light on GBS pathogenesis. In this study, we identified a...
Bacterial InfectionsGenome-Wide Assessment of Streptococcus agalactiae Genes Required for Survival in Human Whole Blood and PlasmaStreptococcus agalactiae (group B streptococcus, or GBS) is a common cause of bacteremia and sepsis in newborns, pregnant women, and immunocompromised patients. The molecular mechanisms used by GBS to survive and proliferate in blood are not well understood. Here, using a highly virulent GBS strain and transposon-directed insertion site sequencing (TraDIS), we...
Cellular Microbiology: Pathogen-Host Cell Molecular InteractionsModulation of Death and Inflammatory Signaling in Decidual Stromal Cells following Exposure to Group B StreptococcusGroup B Streptococcus (GBS) is an opportunistic bacterial pathogen that contributes to miscarriage, preterm birth, and serious neonatal infections. Studies have indicated that some multilocus sequence types (STs) of GBS are more likely to cause severe disease than others. We hypothesized that the ability of GBS to elicit varying host responses in maternal decidual tissue during pregnancy is an important factor regulating...
- Host-Associated Microbial CommunitiesA Vaginal Tract Signal Detected by the Group B Streptococcus SaeRS System Elicits Transcriptomic Changes and Enhances Murine Colonization