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Streptococcus pneumoniae

  • <em>Streptococcus pneumoniae</em> Elaborates Persistent and Prolonged Competent State during Pneumonia-Derived Sepsis
    Molecular Pathogenesis | Spotlight
    Streptococcus pneumoniae Elaborates Persistent and Prolonged Competent State during Pneumonia-Derived Sepsis

    The competence regulon of pneumococcus regulates both genetic transformation and virulence. However, competence induction during host infection has not been examined. By using the serotype 2 strain D39, we transcriptionally fused the firefly luciferase (luc) to competence-specific genes and spatiotemporally monitored the competence development in a mouse model of pneumonia-derived sepsis. In contrast to the universally reported...

    Jingjun Lin, Pyunghun Park, Hua Li, Myung Whan Oh, Iwona T. Dobrucki, Wawrzyniec Dobrucki, Gee W. Lau
  • Interleukin 17 Receptor E (IL-17RE) and IL-17C Mediate the Recruitment of Neutrophils during Acute <em>Streptococcus pneumoniae</em> Pneumonia
    Host Response and Inflammation
    Interleukin 17 Receptor E (IL-17RE) and IL-17C Mediate the Recruitment of Neutrophils during Acute Streptococcus pneumoniae Pneumonia

    Neutrophils contribute to lung injury in acute pneumococcal pneumonia. The interleukin 17 receptor E (IL-17RE) is the functional receptor for the epithelial-derived cytokine IL-17C, which is known to mediate innate immune functions. The aim of this study was to investigate the contribution of IL-17RE/IL-17C to pulmonary inflammation in a mouse model of acute Streptococcus...

    Patrick Steck, Felix Ritzmann, Anja Honecker, Giovanna Vella, Christian Herr, Rosmarie Gaupp, Markus Bischoff, Timotheus Speer, Thomas Tschernig, Robert Bals, Christoph Beisswenger
  • DprA-Dependent Exit from the Competent State Regulates Multifaceted <span class="named-content genus-species" id="named-content-1">Streptococcus pneumoniae</span> Virulence
    Molecular Pathogenesis
    DprA-Dependent Exit from the Competent State Regulates Multifaceted Streptococcus pneumoniae Virulence

    Streptococcus pneumoniae (pneumococcus) causes multiple infectious diseases. The pneumococcal competence system facilitates genetic transformation, spreads antibiotic resistance, and contributes to virulence. DNA-processing protein A (DprA) regulates the exit of pneumococcus from the competent state. Previously, we have shown that DprA is important in both bacteremia...

    Jingjun Lin, Gee W. Lau
  • Open Access
    A Novel, Multiple-Antigen Pneumococcal Vaccine Protects against Lethal <em>Streptococcus pneumoniae</em> Challenge
    Microbial Immunity and Vaccines | Spotlight
    A Novel, Multiple-Antigen Pneumococcal Vaccine Protects against Lethal Streptococcus pneumoniae Challenge

    Current vaccination against Streptococcus pneumoniae uses vaccines based on capsular polysaccharides from selected serotypes and has led to nonvaccine serotype replacement disease. We have investigated an alternative serotype-independent approach, using multiple-antigen vaccines (MAV) prepared from S....

    Win-Yan Chan, Claire Entwisle, Giuseppe Ercoli, Elise Ramos-Sevillano, Ann McIlgorm, Paola Cecchini, Christopher Bailey, Oliver Lam, Gail Whiting, Nicola Green, David Goldblatt, Jun X. Wheeler, Jeremy S. Brown
  • The Pneumococcal Surface Proteins PspA and PspC Sequester Host C4-Binding Protein To Inactivate Complement C4b on the Bacterial Surface
    Host Response and Inflammation
    The Pneumococcal Surface Proteins PspA and PspC Sequester Host C4-Binding Protein To Inactivate Complement C4b on the Bacterial Surface

    Complement is a critical component of antimicrobial immunity. Various complement regulatory proteins prevent host cells from being attacked.

    Kashif S. Haleem, Youssif M. Ali, Hasan Yesilkaya, Thomas Kohler, Sven Hammerschmidt, Peter W. Andrew, Wilhelm J. Schwaeble, Nicholas J. Lynch
  • Screening for Th17-Dependent Pneumococcal Vaccine Antigens: Comparison of Murine and Human Cellular Immune Responses
    Microbial Immunity and Vaccines | Spotlight
    Screening for Th17-Dependent Pneumococcal Vaccine Antigens: Comparison of Murine and Human Cellular Immune Responses

    Conjugate vaccines against Streptococcus pneumoniae have significantly reduced the incidence of diseases caused by the serotypes included in those vaccines; however, there is still a need for vaccines that confer serotype-independent protection. In the current study, we have constructed a library of conserved surface proteins from...

    Ying-Jie Lu, Elizabeth Oliver, Fan Zhang, Caroline Pope, Adam Finn, Richard Malley
  • Desialylation of Platelets by Pneumococcal Neuraminidase A Induces ADP-Dependent Platelet Hyperreactivity
    Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    Desialylation of Platelets by Pneumococcal Neuraminidase A Induces ADP-Dependent Platelet Hyperreactivity

    Platelets are increasingly recognized to play a role in the complications of Streptococcus pneumoniae infections. S. pneumoniae expresses neuraminidases, which may alter glycans on the platelet surface.

    Vesla Kullaya, Marien I. de Jonge, Jeroen D. Langereis, Christa E. van der Gaast-de Jongh, Christian Büll, Gosse J. Adema, Dirk Lefeber, Amelieke J. Cremers, Blandina T. Mmbaga, Phillip G. de Groot, Quirijn de Mast, Andre J. van der Ven
  • Bacterial Infections
    Novel Immunoprotective Proteins of Streptococcus pneumoniae Identified by Opsonophagocytosis Killing Screen

    The success of polysaccharide conjugate vaccines represents a major advance in the prevention of pneumococcal disease, but the power of these vaccines is limited by partial spectrum of coverage and high cost. Vaccines using immunoprotective proteins are a promising alternative type of pneumococcal vaccines.

    Yang Wang, Zhensong Wen, Xiaolei Pan, David E. Briles, Yongqun He, Jing-Ren Zhang
  • Cellular Microbiology: Pathogen-Host Cell Molecular Interactions | Spotlight
    Enzymatic Hydrolysis of Pneumococcal Capsular Polysaccharide Renders the Bacterium Vulnerable to Host Defense

    Despite a century of investigation, Streptococcus pneumoniae remains a major human pathogen, causing a number of diseases, such as pneumonia, meningitis, and otitis media. Like many encapsulated pathogens, the capsular polysaccharide (CPS) of S. pneumoniae is a critical component for colonization...

    Dustin R. Middleton, Amy V. Paschall, Jeremy A. Duke, Fikri Y. Avci
  • Microbial Immunity and Vaccines
    A Capsular Polysaccharide-Specific Antibody Alters Streptococcus pneumoniae Gene Expression during Nasopharyngeal Colonization of Mice
    Christopher R. Doyle, Jee-Young Moon, Johanna P. Daily, Tao Wang, Liise-anne Pirofski

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