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Infection and Immunity
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Toll-like receptor 4

  • Open Access
    <span class="named-content genus-species" id="named-content-1">Salmonella enterica</span> Serovar Typhimurium Uses PbgA/YejM To Regulate Lipopolysaccharide Assembly during Bacteremia
    Bacterial Infections | Spotlight
    Salmonella enterica Serovar Typhimurium Uses PbgA/YejM To Regulate Lipopolysaccharide Assembly during Bacteremia

    Salmonella enterica serovar Typhimurium (S. Typhimurium) relies upon the inner membrane protein PbgA to enhance outer membrane (OM) integrity and promote virulence in mice. The PbgA transmembrane domain (residues 1 to 190) is essential for viability, while the periplasmic domain (residues 191 to 586) is dispensable. Residues within the basic region (residues...

    Melina B. Cian, Nicole P. Giordano, Revathi Masilamani, Keaton E. Minor, Zachary D. Dalebroux
  • <em>Salmonella</em> Fimbrial Protein FimH Is Involved in Expression of Proinflammatory Cytokines in a Toll-Like Receptor 4-Dependent Manner
    Host Response and Inflammation
    Salmonella Fimbrial Protein FimH Is Involved in Expression of Proinflammatory Cytokines in a Toll-Like Receptor 4-Dependent Manner

    Type 1 fimbriae are proteinaceous filamentous structures present on bacterial surfaces and are mainly composed of the major fimbrial protein subunit FimA and the adhesive protein FimH, which is located at the tip of the fimbrial shaft. Here, we investigated the involvement of type 1 fimbriae in the expression of proinflammatory cytokines in macrophages infected with ...

    Kei-ichi Uchiya, Yurie Kamimura, Ayumi Jusakon, Toshiaki Nikai
  • Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    Activation of Porcine Alveolar Macrophages by Actinobacillus pleuropneumoniae Lipopolysaccharide via the Toll-Like Receptor 4/NF-κB-Mediated Pathway
    Bi Li, Jing Fang, Zhicai Zuo, Sirui Yin, Tingting He, Mingxian Yang, Junliang Deng, Liuhong Shen, Xiaoping Ma, Shumin Yu, Ya Wang, Zhihua Ren
  • Bacterial Infections
    Porphyromonas gulae Activates Unprimed and Gamma Interferon-Primed Macrophages via the Pattern Recognition Receptors Toll-Like Receptor 2 (TLR2), TLR4, and NOD2
    James A. Holden, Neil M. O'Brien-Simpson, Jason C. Lenzo, Rebecca K. H. Orth, Ashley Mansell, Eric C. Reynolds
  • Free
    Fungal and Parasitic Infections | Spotlight
    Acanthamoeba Activates Macrophages Predominantly through Toll-Like Receptor 4- and MyD88-Dependent Mechanisms To Induce Interleukin-12 (IL-12) and IL-6
    Antonella Cano, Antonella Mattana, Stuart Woods, Fiona L. Henriquez, James Alexander, Craig W. Roberts
  • Host Response and Inflammation
    Role of MyD88 and Toll-Like Receptors 2 and 4 in the Sensing of Parachlamydia acanthamoebae
    Thierry Roger, Nicola Casson, Antony Croxatto, José Manuel Entenza, Marc Pusztaszeri, Shizuo Akira, Marlies Knaup Reymond, Didier Le Roy, Thierry Calandra, Gilbert Greub
  • Cellular Microbiology: Pathogen-Host Cell Molecular Interactions | Spotlight
    Optimal CD8 T-Cell Response against Encephalitozoon cuniculi Is Mediated by Toll-Like Receptor 4 Upregulation by Dendritic Cells
    Elizabeth M. Lawlor, Magali M. Moretto, Imtiaz A. Khan
  • Fungal and Parasitic Infections
    Toll-Like Receptor 4 Signaling Leads to Severe Fungal Infection Associated with Enhanced Proinflammatory Immunity and Impaired Expansion of Regulatory T Cells
    Flávio V. Loures, Adriana Pina, Maíra Felonato, Eliseu F. Araújo, Katia R. M. Leite, Vera L. G. Calich
  • Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    Helicobacter pylori Lipopolysaccharides Upregulate Toll-Like Receptor 4 Expression and Proliferation of Gastric Epithelial Cells via the MEK1/2-ERK1/2 Mitogen-Activated Protein Kinase Pathway
    Shin-ichi Yokota, Tamaki Okabayashi, Michael Rehli, Nobuhiro Fujii, Ken-ichi Amano
  • Host Response and Inflammation
    Toll-Like Receptors 2 and 4 Contribute to Sepsis-Induced Depletion of Spleen Dendritic Cells
    Frédéric Pène, Emilie Courtine, Fatah Ouaaz, Benjamin Zuber, Bertrand Sauneuf, Gonzalo Sirgo, Christophe Rousseau, Julie Toubiana, Viviane Balloy, Michel Chignard, Jean-Paul Mira, Jean-Daniel Chiche

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