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two-component regulatory systems

  • Regulation of Virulence by Two-Component Systems in Pathogenic <em>Burkholderia</em>
    Minireview
    Regulation of Virulence by Two-Component Systems in Pathogenic Burkholderia

    The regulation and timely expression of bacterial genes during infection is critical for a pathogen to cause an infection. Bacteria have multiple mechanisms to regulate gene expression in response to their environment, one of which is two-component systems (TCS). TCS have two components. One component is a sensory histidine kinase (HK) that autophosphorylates when activated by a signal. The activated sensory histidine kinase then...

    Matthew M. Schaefers
  • <span class="named-content genus-species" id="named-content-1">Vibrio cholerae</span> OmpR Represses the ToxR Regulon in Response to Membrane Intercalating Agents That Are Prevalent in the Human Gastrointestinal Tract
    Molecular Pathogenesis
    Vibrio cholerae OmpR Represses the ToxR Regulon in Response to Membrane Intercalating Agents That Are Prevalent in the Human Gastrointestinal Tract

    Multidrug efflux systems belonging to the resistance-nodulation-division (RND) superfamily are ubiquitous in Gram-negative bacteria. RND efflux systems are often associated with multiple antimicrobial resistance and also contribute to the expression of diverse bacterial phenotypes including virulence, as documented in the intestinal pathogen Vibrio cholerae, the...

    D. E. Kunkle, T. F. Bina, X. R. Bina, J. E. Bina
  • CitAB Two-Component System-Regulated Citrate Utilization Contributes to <em>Vibrio cholerae</em> Competitiveness with the Gut Microbiota
    Molecular Pathogenesis
    CitAB Two-Component System-Regulated Citrate Utilization Contributes to Vibrio cholerae Competitiveness with the Gut Microbiota

    Citrate is a ubiquitous compound and can be utilized by many bacterial species, including enteric pathogens, as a carbon and energy source. Genes involved in citrate utilization have been extensively studied in some enteric bacteria, such as Klebsiella pneumoniae; however, their role in pathogenesis is still not clear.

    Ming Liu, Guijuan Hao, Zhe Li, Yitian Zhou, Reyna Garcia-Sillas, Jie Li, Hui Wang, Biao Kan, Jun Zhu
  • <span class="named-content genus-species" id="named-content-1">Mycobacterium tuberculosis</span> Requires Regulation of ESX-5 Secretion for Virulence in Irgm1-Deficient Mice
    Bacterial Infections
    Mycobacterium tuberculosis Requires Regulation of ESX-5 Secretion for Virulence in Irgm1-Deficient Mice

    The Mycobacterium tuberculosis type VII secretion system ESX-5, which has been implicated in virulence, is activated at the transcriptional level by the phosphate starvation-responsive Pst/SenX3-RegX3 signal transduction system. Deletion of pstA1, which encodes a Pst phosphate transporter component, causes constitutive activation of the response regulator...

    Sarah R. Elliott, Dylan W. White, Anna D. Tischler
  • Bacterial Infections | Spotlight
    Characterization of a Two-Component System Transcriptional Regulator, LtdR, That Impacts Group B Streptococcal Colonization and Disease
    Liwen Deng, Rong Mu, Thomas A. Weston, Brady L. Spencer, Roxanne P. Liles, Kelly S. Doran
  • Molecular Pathogenesis
    High-Salt Conditions Alter Transcription of Helicobacter pylori Genes Encoding Outer Membrane Proteins
    John T. Loh, Amber C. Beckett, Matthew B. Scholz, Timothy L. Cover
  • Molecular Pathogenesis
    The Staphylococcus aureus AirSR Two-Component System Mediates Reactive Oxygen Species Resistance via Transcriptional Regulation of Staphyloxanthin Production
    Jeffrey W. Hall, Junshu Yang, Haiyong Guo, Yinduo Ji
  • Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    Systematic Analysis of Two-Component Systems in Citrobacter rodentium Reveals Positive and Negative Roles in Virulence
    Jenny-Lee Thomassin, Jean-Mathieu Leclerc, Natalia Giannakopoulou, Lei Zhu, Kristiana Salmon, Andrea Portt, France Daigle, Hervé Le Moual, Samantha Gruenheid
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