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type III secretion system

  • <span class="named-content genus-species" id="named-content-1">Pseudomonas aeruginosa</span> ExsA Regulates a Metalloprotease, ImpA, That Inhibits Phagocytosis of Macrophages
    Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    Pseudomonas aeruginosa ExsA Regulates a Metalloprotease, ImpA, That Inhibits Phagocytosis of Macrophages

    Pseudomonas aeruginosa is an opportunistic pathogenic bacterium whose type III secretion system (T3SS) plays a critical role in acute infections. Translocation of the T3SS effectors into host cells induces cytotoxicity. In addition, the T3SS promotes the intracellular growth of P. aeruginosa during...

    Zhenyang Tian, Sen Cheng, Bin Xia, Yongxin Jin, Fang Bai, Zhihui Cheng, Shouguang Jin, Xiaoyun Liu, Weihui Wu
  • EspH Suppresses Erk by Spatial Segregation from CD81 Tetraspanin Microdomains
    Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    EspH Suppresses Erk by Spatial Segregation from CD81 Tetraspanin Microdomains

    Enteropathogenic Escherichia coli (EPEC) belongs to a group of enteric human pathogens known as attaching-and-effacing (A/E) pathogens, which utilize a type III secretion system (T3SS) to translocate a battery of effector proteins from their own cytoplasm into host intestinal epithelial cells. Here we identified EspH to be an effector that prompts the recruitment of...

    Rachana Pattani Ramachandran, Felipe Vences-Catalán, Dan Wiseman, Efrat Zlotkin-Rivkin, Eyal Shteyer, Naomi Melamed-Book, Ilan Rosenshine, Shoshana Levy, Benjamin Aroeti
  • Microbial Immunity and Vaccines
    Characterization and Protective Efficacy of Type III Secretion Proteins as a Broadly Protective Subunit Vaccine against Salmonella enterica Serotypes
    Francisco J. Martinez-Becerra, Prashant Kumar, Vikalp Vishwakarma, Jae Hyun Kim, Olivia Arizmendi, C. Russell Middaugh, William D. Picking, Wendy L. Picking
  • Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    Tricellular Tight Junction Protein Tricellulin Is Targeted by the Enteropathogenic Escherichia coli Effector EspG1, Leading to Epithelial Barrier Disruption
    Vijay Morampudi, Franziska A. Graef, Martin Stahl, Udit Dalwadi, Victoria S. Conlin, Tina Huang, Bruce A. Vallance, Hong B. Yu, Kevan Jacobson
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