type III secretion system
Cellular Microbiology: Pathogen-Host Cell Molecular InteractionsPseudomonas aeruginosa ExsA Regulates a Metalloprotease, ImpA, That Inhibits Phagocytosis of MacrophagesPseudomonas aeruginosa is an opportunistic pathogenic bacterium whose type III secretion system (T3SS) plays a critical role in acute infections. Translocation of the T3SS effectors into host cells induces cytotoxicity. In addition, the T3SS promotes the intracellular growth of P. aeruginosa during...
Cellular Microbiology: Pathogen-Host Cell Molecular InteractionsEspH Suppresses Erk by Spatial Segregation from CD81 Tetraspanin MicrodomainsEnteropathogenic Escherichia coli (EPEC) belongs to a group of enteric human pathogens known as attaching-and-effacing (A/E) pathogens, which utilize a type III secretion system (T3SS) to translocate a battery of effector proteins from their own cytoplasm into host intestinal epithelial cells. Here we identified EspH to be an effector that prompts the recruitment of...
- Cellular Microbiology: Pathogen-Host Cell Molecular InteractionsTricellular Tight Junction Protein Tricellulin Is Targeted by the Enteropathogenic Escherichia coli Effector EspG1, Leading to Epithelial Barrier Disruption