type IV secretion system
Molecular PathogenesisIdentification of Pathogenicity Island Genes Associated with Loss of Type IV Secretion Function during Murine Infection with Helicobacter pyloriChronic Helicobacter pylori colonization in animal models often leads to downregulation of the type IV secretion system (T4SS), typically by recombination in cagY, which is an essential T4SS gene. However, 17 other cag pathogenicity island (cagPAI) genes, as well as some non-cagPAI genes, are also essential for T4SS function. To get...
Molecular PathogenesisEirA Is a Novel Protein Essential for Intracellular Replication of Coxiella burnetiiThe zoonotic bacterial pathogen Coxiella burnetii is the causative agent of Q fever, a febrile illness which can cause a serious chronic infection. C. burnetii is a unique intracellular bacterium which replicates within host lysosome-derived vacuoles. The ability of...
Cellular Microbiology: Pathogen-Host Cell Molecular InteractionsA Chemical Genetics Screen Reveals Influence of p38 Mitogen-Activated Protein Kinase and Autophagy on Phagosome Development and Intracellular Replication of Brucella neotomae in MacrophagesBrucella is an intracellular bacterial pathogen that causes chronic systemic infection in domesticated livestock and poses a zoonotic infectious risk to humans. The virulence of Brucella is critically dependent on its ability to replicate and survive within host macrophages. Brucella modulates host physiological pathways and cell biology in order to establish a productive intracellular replicative niche....
Bacterial InfectionsBrucella neotomae Recapitulates Attributes of Zoonotic Human Disease in a Murine Infection ModelMembers of the genus Brucella are Gram-negative pathogens that cause chronic systemic infection in farm animals and zoonotic infection in humans. Study of the genus Brucella has been hindered by the need for biosafety level 3 select agent containment.
- Cellular Microbiology: Pathogen-Host Cell Molecular Interactions | SpotlightBrucella abortus Senses the Intracellular Environment through the BvrR/BvrS Two-Component System, Which Allows B. abortus To Adapt to Its Replicative Niche
- Cellular Microbiology: Pathogen-Host Cell Molecular InteractionsPromotion and Rescue of Intracellular Brucella neotomae Replication during Coinfection with Legionella pneumophila