typhoid fever

Molecular Pathogenesis
Generation and Characterization of Typhoid Toxin-Neutralizing Human Monoclonal Antibodies
Typhoid toxin is a virulence factor of Salmonella enterica serovar Typhi, the causative agent of typhoid fever, and is thought to be responsible for the symptoms of severe disease. This toxin has a unique A2B5 architecture with two active subunits, the ADP ribosyl transferase PltA and the DNase CdtB, linked to a pentameric B subunit, which is alternatively made of...

Xuyao Jiao, Sarah Smith, Gabrielle Stack, Qi Liang, Allan Bradley, Paul Kellam, Jorge E. Galán
Open Access

Bacterial Infections
Comparison of Salmonella enterica Serovars Typhi and Typhimurium Reveals Typhoidal Serovar-Specific Responses to Bile
Rebecca Johnson, Matt Ravenhall, Derek Pickard, Gordon Dougan, Alexander Byrne, Gad Frankel
Host Response and Inflammation
Gamma Interferon-Independent Effects of Interleukin-12 on Immunity to Salmonella enterica Serovar Typhimurium
Jason D. Price, Kim R. Simpfendorfer, Radhakrishnam R. Mantena, James Holden, William R. Heath, Nico van Rooijen, Richard A. Strugnell, Odilia L. C. Wijburg
Bacterial Infections
Serologic Evidence for Effective Production of Cytolysin A in Salmonella enterica Serovars Typhi and Paratyphi A during Human Infection
Christine von Rhein, Klaus-Peter Hunfeld, Albrecht Ludwig
Molecular Pathogenesis
Identification of In Vivo-Induced Bacterial Protein Antigens during Human Infection with Salmonella enterica Serovar Typhi
Jason B. Harris, Andrea Baresch-Bernal, Sean M. Rollins, Ashfaqul Alam, Regina C. LaRocque, Margaret Bikowski, Amanda F. Peppercorn, Martin Handfield, Jeffery D. Hillman, Firdausi Qadri, Stephen B. Calderwood, Elizabeth Hohmann, Robert F. Breiman, W. Abdullah Brooks, Edward T. Ryan
MINIREVIEWS
Capsule-Mediated Immune Evasion: a New Hypothesis Explaining Aspects of Typhoid Fever Pathogenesis
Manuela Raffatellu, Daniela Chessa, R. Paul Wilson, Çagla Tükel, Mustafa Akçelik, Andreas J. Bäumler
Host Response and Inflammation
Secreted Effector Proteins of Salmonella enterica Serotype Typhimurium Elicit Host-Specific Chemokine Profiles in Animal Models of Typhoid Fever and Enterocolitis
Shuping Zhang, L. Garry Adams, Jairo Nunes, Sangeeta Khare, Renée M. Tsolis, Andreas J. Bäumler
Microbial Immunity and Vaccines
Salmonella enterica Serovar Typhi Live Vector Vaccines Delivered Intranasally Elicit Regional and Systemic Specific CD8⁺ Major Histocompatibility Class I-Restricted Cytotoxic T Lymphocytes
Marcela F. Pasetti, Rosangela Salerno-Gonçalves, Marcelo B. Sztein
Bacterial Infections
Flagellar Phase Variation of Salmonella enterica Serovar Typhimurium Contributes to Virulence in the Murine Typhoid Infection Model but Does Not InfluenceSalmonella-Induced Enteropathogenesis
Jack S. Ikeda, Clare K. Schmitt, Stephen C. Darnell, Patricia R. Watson, Jennifer Bispham, Timothy S. Wallis, Debra L. Weinstein, Eleanor S. Metcalf, Phillip Adams, C. David O'Connor, Alison D. O'Brien
Molecular Pathogenesis
mig-14 Is a Horizontally Acquired, Host-Induced Gene Required for Salmonella enterica Lethal Infection in the Murine Model of Typhoid Fever
Raphael H. Valdivia, Daniela M. Cirillo, Anthea K. Lee, Donna M. Bouley, Stanley Falkow

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