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Infection and Immunity
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typhoid fever

  • Generation and Characterization of Typhoid Toxin-Neutralizing Human Monoclonal Antibodies
    Molecular Pathogenesis
    Generation and Characterization of Typhoid Toxin-Neutralizing Human Monoclonal Antibodies

    Typhoid toxin is a virulence factor of Salmonella enterica serovar Typhi, the causative agent of typhoid fever, and is thought to be responsible for the symptoms of severe disease. This toxin has a unique A2B5 architecture with two active subunits, the ADP ribosyl transferase PltA and the DNase CdtB, linked to a pentameric B subunit, which is alternatively made of...

    Xuyao Jiao, Sarah Smith, Gabrielle Stack, Qi Liang, Allan Bradley, Paul Kellam, Jorge E. Galán
  • Open Access
    Bacterial Infections
    Comparison of Salmonella enterica Serovars Typhi and Typhimurium Reveals Typhoidal Serovar-Specific Responses to Bile
    Rebecca Johnson, Matt Ravenhall, Derek Pickard, Gordon Dougan, Alexander Byrne, Gad Frankel
  • Host Response and Inflammation
    Gamma Interferon-Independent Effects of Interleukin-12 on Immunity to Salmonella enterica Serovar Typhimurium
    Jason D. Price, Kim R. Simpfendorfer, Radhakrishnam R. Mantena, James Holden, William R. Heath, Nico van Rooijen, Richard A. Strugnell, Odilia L. C. Wijburg
  • Bacterial Infections
    Serologic Evidence for Effective Production of Cytolysin A in Salmonella enterica Serovars Typhi and Paratyphi A during Human Infection
    Christine von Rhein, Klaus-Peter Hunfeld, Albrecht Ludwig
  • Molecular Pathogenesis
    Identification of In Vivo-Induced Bacterial Protein Antigens during Human Infection with Salmonella enterica Serovar Typhi
    Jason B. Harris, Andrea Baresch-Bernal, Sean M. Rollins, Ashfaqul Alam, Regina C. LaRocque, Margaret Bikowski, Amanda F. Peppercorn, Martin Handfield, Jeffery D. Hillman, Firdausi Qadri, Stephen B. Calderwood, Elizabeth Hohmann, Robert F. Breiman, W. Abdullah Brooks, Edward T. Ryan
  • MINIREVIEWS
    Capsule-Mediated Immune Evasion: a New Hypothesis Explaining Aspects of Typhoid Fever Pathogenesis
    Manuela Raffatellu, Daniela Chessa, R. Paul Wilson, Çagla Tükel, Mustafa Akçelik, Andreas J. Bäumler
  • Host Response and Inflammation
    Secreted Effector Proteins of Salmonella enterica Serotype Typhimurium Elicit Host-Specific Chemokine Profiles in Animal Models of Typhoid Fever and Enterocolitis
    Shuping Zhang, L. Garry Adams, Jairo Nunes, Sangeeta Khare, Renée M. Tsolis, Andreas J. Bäumler
  • Microbial Immunity and Vaccines
    Salmonella enterica Serovar Typhi Live Vector Vaccines Delivered Intranasally Elicit Regional and Systemic Specific CD8+ Major Histocompatibility Class I-Restricted Cytotoxic T Lymphocytes
    Marcela F. Pasetti, Rosangela Salerno-Gonçalves, Marcelo B. Sztein
  • Bacterial Infections
    Flagellar Phase Variation of Salmonella enterica Serovar Typhimurium Contributes to Virulence in the Murine Typhoid Infection Model but Does Not InfluenceSalmonella-Induced Enteropathogenesis
    Jack S. Ikeda, Clare K. Schmitt, Stephen C. Darnell, Patricia R. Watson, Jennifer Bispham, Timothy S. Wallis, Debra L. Weinstein, Eleanor S. Metcalf, Phillip Adams, C. David O'Connor, Alison D. O'Brien
  • Molecular Pathogenesis
    mig-14 Is a Horizontally Acquired, Host-Induced Gene Required for Salmonella enterica Lethal Infection in the Murine Model of Typhoid Fever
    Raphael H. Valdivia, Daniela M. Cirillo, Anthea K. Lee, Donna M. Bouley, Stanley Falkow

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