whooping cough
- Microbial Immunity and Vaccines | SpotlightIntranasal Immunization with Acellular Pertussis Vaccines Results in Long-Term Immunity to Bordetella pertussis in Mice
Bordetella pertussis colonizes the respiratory mucosa of humans, inducing an immune response seeded in the respiratory tract. An individual, once convalescent, exhibits long-term immunity to the pathogen.
- Microbial Immunity and VaccinesEvaluation of Adenylate Cyclase Toxoid Antigen in Acellular Pertussis Vaccines by Using a Bordetella pertussis Challenge Model in Mice
Bordetella pertussis is the primary causative agent of pertussis (whooping cough), which is a respiratory infection that leads to a violent cough and can be fatal in infants. There is a need to develop more effective vaccines because of the resurgence of cases of pertussis in the United States since the switch from the whole-cell pertussis vaccines (wP) to the...
- Microbial Immunity and VaccinesCharacterization of Individual Human Antibodies That Bind Pertussis Toxin Stimulated by Acellular Immunization
- Cellular Microbiology: Pathogen-Host Cell Molecular InteractionsCyclic AMP-Elevating Capacity of Adenylate Cyclase Toxin-Hemolysin Is Sufficient for Lung Infection but Not for Full Virulence of Bordetella pertussis
- Cellular Microbiology: Pathogen-Host Cell Molecular InteractionsProtective Role of Passively Transferred Maternal Cytokines against Bordetella pertussis Infection in Newborn Piglets