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Infection and Immunity
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whooping cough

  • Open Access
    Intranasal Immunization with Acellular Pertussis Vaccines Results in Long-Term Immunity to <span class="named-content genus-species" id="named-content-1">Bordetella pertussis</span> in Mice
    Microbial Immunity and Vaccines | Spotlight
    Intranasal Immunization with Acellular Pertussis Vaccines Results in Long-Term Immunity to Bordetella pertussis in Mice

    Bordetella pertussis colonizes the respiratory mucosa of humans, inducing an immune response seeded in the respiratory tract. An individual, once convalescent, exhibits long-term immunity to the pathogen.

    M. Allison Wolf, Dylan T. Boehm, Megan A. DeJong, Ting Y. Wong, Emel Sen-Kilic, Jesse M. Hall, Catherine B. Blackwood, Kelly L. Weaver, Claire O. Kelly, Caleb A. Kisamore, Graham J. Bitzer, Justin R. Bevere, Mariette Barbier, F. Heath Damron
  • Evaluation of Adenylate Cyclase Toxoid Antigen in Acellular Pertussis Vaccines by Using a <span class="named-content genus-species" id="named-content-1">Bordetella pertussis</span> Challenge Model in Mice
    Microbial Immunity and Vaccines
    Evaluation of Adenylate Cyclase Toxoid Antigen in Acellular Pertussis Vaccines by Using a Bordetella pertussis Challenge Model in Mice

    Bordetella pertussis is the primary causative agent of pertussis (whooping cough), which is a respiratory infection that leads to a violent cough and can be fatal in infants. There is a need to develop more effective vaccines because of the resurgence of cases of pertussis in the United States since the switch from the whole-cell pertussis vaccines (wP) to the...

    Dylan T. Boehm, Jesse M. Hall, Ting Y. Wong, Andrea M. DiVenere, Emel Sen-Kilic, Justin R. Bevere, Shelby D. Bradford, Catherine B. Blackwood, Cody M. Elkins, Katherine A. DeRoos, Mary C. Gray, C. Garret Cooper, Melinda E. Varney, Jennifer A. Maynard, Erik L. Hewlett, Mariette Barbier, F. Heath Damron
  • Open Access
    Microbial Immunity and Vaccines
    Characterization of Individual Human Antibodies That Bind Pertussis Toxin Stimulated by Acellular Immunization
    Edith Acquaye-Seedah, Elizabeth E. Reczek, Hugh H. Russell, Andrea M. DiVenere, Sara O. Sandman, Joseph H. Collins, Caitlin A. Stein, Timothy A. Whitehead, Jennifer A. Maynard
  • Bacterial Infections
    Screening and Genomic Characterization of Filamentous Hemagglutinin-Deficient Bordetella pertussis
    Michael R. Weigand, Lucia C. Pawloski, Yanhui Peng, Hong Ju, Mark Burroughs, Pamela K. Cassiday, Jamie K. Davis, Marina DuVall, Taccara Johnson, Phalasy Juieng, Kristen Knipe, Vladimir N. Loparev, Marsenia H. Mathis, Lori A. Rowe, Mili Sheth, Margaret M. Williams, M. Lucia Tondella
  • Bacterial Infections
    Hyperbiofilm Formation by Bordetella pertussis Strains Correlates with Enhanced Virulence Traits
    Natalia Cattelan, Jamie Jennings-Gee, Purnima Dubey, Osvaldo M. Yantorno, Rajendar Deora
  • Bacterial Infections
    Fatal Pertussis in the Neonatal Mouse Model Is Associated with Pertussis Toxin-Mediated Pathology beyond the Airways
    Karen M. Scanlon, Yael G. Snyder, Ciaran Skerry, Nicholas H. Carbonetti
  • Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    Cyclic AMP-Elevating Capacity of Adenylate Cyclase Toxin-Hemolysin Is Sufficient for Lung Infection but Not for Full Virulence of Bordetella pertussis
    Karolina Skopova, Barbora Tomalova, Ivan Kanchev, Pavel Rossmann, Martina Svedova, Irena Adkins, Ilona Bibova, Jakub Tomala, Jiri Masin, Nicole Guiso, Radim Osicka, Radislav Sedlacek, Marek Kovar, Peter Sebo
  • Bacterial Infections
    Albumin, in the Presence of Calcium, Elicits a Massive Increase in Extracellular Bordetella Adenylate Cyclase Toxin
    Laura A. Gonyar, Mary C. Gray, Gregory J. Christianson, Borna Mehrad, Erik L. Hewlett
  • Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
    Protective Role of Passively Transferred Maternal Cytokines against Bordetella pertussis Infection in Newborn Piglets
    Shokrollah Elahi, David R. Thompson, Jill Van Kessel, Lorne A. Babiuk, Volker Gerdts
  • Microbial Immunity and Vaccines
    Cross-Species Protection Mediated by a Bordetella bronchiseptica Strain Lacking Antigenic Homologs Present in Acellular Pertussis Vaccines
    Neelima Sukumar, Gina Parise Sloan, Matt S. Conover, Cheraton F. Love, Seema Mattoo, Nancy D. Kock, Rajendar Deora

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