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Cellular Microbiology: Pathogen-Host Cell Molecular InteractionsCharacterization of Early Stages of Human Alveolar Infection by the Q Fever Agent Coxiella burnetiiHuman Q fever is caused by the intracellular bacterial pathogen Coxiella burnetii. Q fever presents with acute flu-like and pulmonary symptoms or can progress to chronic, severe endocarditis.
Host Response and Inflammation | SpotlightTranscriptional Analysis Shows a Robust Host Response to Toxoplasma gondii during Early and Late Chronic Infection in Both Male and Female MiceThe long-term host effects caused by the protozoan parasite Toxoplasma gondii are poorly understood. High-throughput RNA sequencing analysis previously determined that the host response in the brain was greater and more complex at 28 days than at 10 days postinfection.
Molecular Pathogenesis | SpotlightControl of Staphylococcus aureus Quorum Sensing by a Membrane-Embedded Peptidase...Gram-positive bacteria process and release small peptides, or pheromones, that act as signals for the induction of adaptive traits, including those involved in pathogenesis. One class of small signaling pheromones is the cyclic autoinducing peptides (AIPs), which regulate expression of genes that orchestrate virulence and persistence in a range of microbes, including staphylococci, listeriae, clostridia, and enterococci.
Host Response and InflammationDietary Chitin Particles Called Mimetic Fungi Ameliorate Colitis in Toll-Like Receptor 2/CD14- and Sex-Dependent MannersChitin is a natural N-acetylglucosamine polymer and a major structural component of fungal cell walls. Dietary chitin is mucoadhesive; anti-inflammatory effects of chitin microparticles (CMPs; 1- to 10-μm diameters) have been demonstrated in models of inflammatory bowel disease (IBD).
Molecular Pathogenesis | SpotlightMroQ Is a Novel Abi-Domain Protein That Influences Virulence Gene Expression in Staphylococcus aureus via Modulation of Agr Activity...Numerous factors have, to date, been identified as playing a role in the regulation of Agr activity in Staphylococcus aureus, including transcription factors, antisense RNAs, and host elements. Herein we investigated the product of SAUSA300_1984 (termed MroQ), a transmembrane Abi-domain/M79 protease-family protein, as a novel effector of this system.
- Cellular Microbiology: Pathogen-Host Cell Molecular InteractionsTet38 of Staphylococcus aureus Binds to Host Cell Receptor Complex CD36/TLR-2 and Protects from Teichoic Acid Synthesis Inhibitors Tunicamycin and Congo Red
- Cellular Microbiology: Pathogen-Host Cell Molecular InteractionsInfection of Primary Human Alveolar Macrophages Alters Staphylococcus aureus Toxin Production and Activity
- Host-Associated Microbial CommunitiesProduction of a Functional Factor, p40, by Lactobacillus rhamnosus GG Is Promoted by Intestinal Epithelial Cell-secreted Extracellular Vesicles