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Infection and Immunity
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Latest Articles

  • Antibodies to Protein but Not Glycolipid Structures Are Important for Host Defense against <span class="named-content genus-species" id="named-content-1">Mycoplasma pneumoniae</span>
    Host Response and Inflammation
    Antibodies to Protein but Not Glycolipid Structures Are Important for Host Defense against Mycoplasma pneumoniae

    Antibody responses to Mycoplasma pneumoniae correlate with pulmonary M. pneumoniae clearance. However, M. pneumoniae-specific IgG antibodies can cross-react with the myelin glycolipid galactocerebroside (GalC) and cause...

    Patrick M. Meyer Sauteur, Adrianus C. J. M. de Bruijn, Catarina Graça, Anne P. Tio-Gillen, Silvia C. Estevão, Theo Hoogenboezem, Rudi W. Hendriks, Christoph Berger, Bart C. Jacobs, Annemarie M. C. van Rossum, Ruth Huizinga, Wendy W. J. Unger
  • <span class="named-content genus-species" id="named-content-1">Mycobacterium tuberculosis</span> Requires Regulation of ESX-5 Secretion for Virulence in Irgm1-Deficient Mice
    Bacterial Infections
    Mycobacterium tuberculosis Requires Regulation of ESX-5 Secretion for Virulence in Irgm1-Deficient Mice

    The Mycobacterium tuberculosis type VII secretion system ESX-5, which has been implicated in virulence, is activated at the transcriptional level by the phosphate starvation-responsive Pst/SenX3-RegX3 signal transduction system. Deletion of pstA1, which encodes a Pst phosphate transporter component, causes constitutive activation of the response regulator...

    Sarah R. Elliott, Dylan W. White, Anna D. Tischler
  • Role of Gonococcal Neisserial Surface Protein A (NspA) in Serum Resistance and Comparison of Its Factor H Binding Properties with Those of Its Meningococcal Counterpart
    Microbial Immunity and Vaccines
    Role of Gonococcal Neisserial Surface Protein A (NspA) in Serum Resistance and Comparison of Its Factor H Binding Properties with Those of Its Meningococcal Counterpart

    Neisseria gonorrhoeae, the causative agent of gonorrhea, has evolved several mechanisms to subvert complement, including binding of the complement inhibitor factor H (FH). We previously reported FH binding to N. gonorrhoeae independently of lipooligosaccharide (LOS) sialylation.

    Lisa A. Lewis, Peter A. Rice, Sanjay Ram
  • Open Access
    Establishment, Validation, and Application of a New World Primate Model of Enterotoxigenic <em>Escherichia coli</em> Disease for Vaccine Development
    Bacterial Infections | Spotlight
    Establishment, Validation, and Application of a New World Primate Model of Enterotoxigenic Escherichia coli Disease for Vaccine Development

    The establishment of an animal model that closely approximates enterotoxigenic Escherichia coli (ETEC) disease in humans is critical for the development and evaluation of vaccines against this enteropathogen. Here, we evaluated the susceptibility of Aotus nancymaae, a New World monkey species, to...

    Julianne E. Rollenhagen, Franca Jones, Eric Hall, Ryan Maves, Gladys Nunez, Nereyda Espinoza, Aisling O'Dowd, Michael G. Prouty, Stephen J. Savarino
  • Open Access
    <span class="named-content genus-species" id="named-content-1">Rickettsia rickettsii</span> Whole-Cell Antigens Offer Protection against Rocky Mountain Spotted Fever in the Canine Host
    Microbial Immunity and Vaccines
    Rickettsia rickettsii Whole-Cell Antigens Offer Protection against Rocky Mountain Spotted Fever in the Canine Host

    Rocky Mountain spotted fever (RMSF) is a potentially fatal tick-borne disease in people and dogs. RMSF is reported in the United States and several countries in North, Central, and South America.

    Andy Alhassan, Huitao Liu, Jodi McGill, Argine Cerezo, Laxmi U. M. R. Jakkula, Arathy D. S. Nair, Emma Winkley, Sally Olson, Denver Marlow, Abha Sahni, Hema P. Narra, Sanjeev Sahni, Jamie Henningson, Roman R. Ganta
  • Nontypeable <span class="named-content genus-species" id="named-content-1">Haemophilus influenzae</span> Invasive Blood Isolates Are Mainly Phosphorylcholine Negative and Show Decreased Complement-Mediated Killing That Is Associated with Lower Binding of IgM and CRP in Comparison to Colonizing Isolates from the Oropharynx
    Molecular Pathogenesis
    Nontypeable Haemophilus influenzae Invasive Blood Isolates Are Mainly Phosphorylcholine Negative and Show Decreased Complement-Mediated Killing That Is Associated with Lower Binding of IgM and CRP in Comparison to Colonizing Isolates from the Oropharynx

    Nontypeable Haemophilus influenzae (NTHi) bacteria express various molecules that contribute to their virulence. The presence of phosphocholine (PCho) on NTHi lipooligosaccharide increases adhesion to epithelial cells and is an advantage for the bacterium, enabling nasopharyngeal colonization, as measured in humans and animal models.

    Jeroen D. Langereis, Amelieke J. H. Cremers, Marloes Vissers, Josine van Beek, Jacques F. Meis, Marien I. de Jonge
  • Peptidoglycan Recognition Protein 4 Suppresses Early Inflammatory Responses to <em>Bordetella pertussis</em> and Contributes to Sphingosine-1-Phosphate Receptor Agonist-Mediated Disease Attenuation
    Host Response and Inflammation
    Peptidoglycan Recognition Protein 4 Suppresses Early Inflammatory Responses to Bordetella pertussis and Contributes to Sphingosine-1-Phosphate Receptor Agonist-Mediated Disease Attenuation

    Incidence of whooping cough (pertussis), a bacterial infection of the respiratory tract caused by the bacterium Bordetella pertussis, has reached levels not seen since the 1950s. Antibiotics fail to improve the course of disease unless administered early in infection.

    Ciaran Skerry, William E. Goldman, Nicholas H. Carbonetti
  • Open Access
    Characterization of the Mode of Action of Aurodox, a Type III Secretion System Inhibitor from <span class="named-content genus-species" id="named-content-1">Streptomyces goldiniensis</span>
    Bacterial Infections
    Characterization of the Mode of Action of Aurodox, a Type III Secretion System Inhibitor from Streptomyces goldiniensis

    Recent work has demonstrated that the polyketide natural product Aurodox from Streptomyces goldiniensis is able to block the pathogenesis of the murine pathogen Citrobacter rodentium. In this work, we aimed to gain a better understanding of the mechanism of action of the compound.

    ...
    Rebecca E. McHugh, Nicky O’Boyle, James P. R. Connolly, Paul A. Hoskisson, Andrew J. Roe
  • Interplay of Nitric Oxide Synthase (NOS) and SrrAB in Modulation of <em>Staphylococcus aureus</em> Metabolism and Virulence
    Molecular Pathogenesis
    Interplay of Nitric Oxide Synthase (NOS) and SrrAB in Modulation of Staphylococcus aureus Metabolism and Virulence

    Staphylococcus aureus nitric oxide synthase (saNOS) is a major contributor to virulence, stress resistance, and physiology, yet the specific mechanism(s) by which saNOS intersects with other known regulatory circuits is largely unknown. The SrrAB two-component system, which modulates gene expression in response to the reduced state of respiratory menaquinones, is a...

    Kimberly L. James, Austin B. Mogen, Jessica N. Brandwein, Silvia S. Orsini, Miranda J. Ridder, Mary A. Markiewicz, Jeffrey L. Bose, Kelly C. Rice
  • PPE37 Is Essential for <em>Mycobacterium tuberculosis</em> Heme-Iron Acquisition (HIA), and a Defective PPE37 in <em>Mycobacterium bovis</em> BCG Prevents HIA
    Molecular Pathogenesis
    PPE37 Is Essential for Mycobacterium tuberculosis Heme-Iron Acquisition (HIA), and a Defective PPE37 in Mycobacterium bovis BCG Prevents HIA

    Mycobacterium tuberculosis, one of the world’s leading causes of death, must acquire nutrients, such as iron, from the host to multiply and cause disease. Iron is an essential metal and M. tuberculosis possesses two different systems to acquire iron from its environment: siderophore-mediated iron...

    Michael V. Tullius, Susana Nava, Marcus A. Horwitz

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