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Bacterial InfectionsAnimal Model To Study Klebsiella pneumoniae Gastrointestinal Colonization and Host-to-Host TransmissionAn important yet poorly understood facet of the life cycle of a successful pathogen is host-to-host transmission. Hospital-acquired infections (HAI) resulting from the transmission of drug-resistant pathogens affect hundreds of millions of patients worldwide. Klebsiella pneumoniae, a Gram-negative bacterium, is notorious for causing HAI, with many of these infections...
- Host Response and InflammationEscherichia coli K12 upregulates PD-L1 expression in IFN-γ sensitized intestinal epithelial cells via the NF-κB pathway
- Host Response and InflammationA. muciniphila and its Pili-like Protein Amuc_1100 Modulate Macrophage Polarization in Experimental Periodontitis
- Host Response and InflammationEffect of CARD9 deficiency on neutrophil-mediated host defense against pulmonary infection with Streptococcus pneumoniae
Minireview | SpotlightThe Great ESKAPE: Exploring the Crossroads of Bile and Antibiotic Resistance in Bacterial PathogensThroughout the course of infection, many pathogens encounter bactericidal conditions that threaten the viability of the bacteria and impede the establishment of infection. Bile is one of the most innately bactericidal compounds present in humans, functioning to reduce the bacterial burden in the gastrointestinal tract while also aiding in digestion. It is becoming increasingly apparent that pathogens successfully resist the bactericidal...
Cellular Microbiology: Pathogen-Host Cell Molecular InteractionsParacellular Pathway-Mediated Mycoplasma hyopneumoniae Migration across Porcine Airway Epithelial Barrier under Air-Liquid Interface ConditionsMycoplasma hyopneumoniae is an important respiratory pathogen of pigs that causes persistent and secondary infections. However, the mechanisms by which this occurs are unclear. In this study, we established air-liquid interface culture systems for pig bronchial epithelial cells (ALI-PBECs) that were comparable to the conditions in the native bronchus in vivo...
