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Bacterial InfectionsTargeting Neuropilin-1 Suppresses the Stability of CD4+ CD25+ Regulatory T Cells via the NF-κB Signaling Pathway in SepsisNeuropilin-1 (Nrp-1) contributes to maintaining the stability of CD4+ CD25+ regulatory T cells (Tregs). We investigated the impact of Nrp-1 on the stability of CD4+ CD25+ Tregs, and the underlying signaling pathways, in a model of sepsis. Splenic CD4+ CD25+ Tregs were either treated with anti-Nrp-1, transfected to silence Nrp-1 and...
Cellular Microbiology: Pathogen-Host Cell Molecular InteractionsMicrobial Lipid A Remodeling Controls Cross-Presentation Efficiency and CD8 T Cell Priming by Modulating Dendritic Cell FunctionThe majority of Gram-negative bacteria elicit a potent immune response via recognition of lipid A expressed on the outer bacterial membrane by the host immune receptor Toll-like receptor 4 (TLR4). However, some Gram-negative bacteria evade detection by TLR4 or alter the outcome of TLR4 signaling by modification of lipid A species.
Bacterial InfectionsCardiotropic Isolates of Listeria monocytogenes with Enhanced Vertical Transmission Dependent upon the Bacterial Surface Protein InlBListeria monocytogenes is a facultative Gram-positive intracellular bacterium that is capable of causing serious invasive infections in pregnant women, resulting in abortion, still-birth, and disseminated fetal infection. Previously, a clinical L. monocytogenes isolate, 07PF0776, was identified as...
Host Response and Inflammation | SpotlightCXCR3-Dependent Immune Pathology in Mice following Infection with Toxoplasma gondii during Early PregnancyToxoplasmosis is a worldwide zoonosis caused by the obligate intracellular parasite Toxoplasma gondii. The symptoms of congenital toxoplasmosis range from embryonic death and resorption to subclinical infection, but the mechanism of disease onset remains unclear.
- Cellular Microbiology: Pathogen-Host Cell Molecular InteractionsElevated Extracellular cGMP Produced after Exposure to Enterotoxigenic Escherichia coli (ETEC) Heat-Stable Toxin (ST) Induces Epithelial IL-33 Release and Alters Intestinal Immunity
- Host Response and InflammationRegulation of the Nfkbiz gene and its protein product lkBζ in animal models of sepsis and endotoxic shock
- Host Response and InflammationIncreased Listeria monocytogenes dissemination and altered population dynamics in Muc2-deficient mice
- Cellular Microbiology: Pathogen-Host Cell Molecular InteractionsProtein and DNA biosynthesis demonstrated in host cell-free phagosomes containing Anaplasma phagocytophilum or Ehrlichia chaffeensis in axenic media