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Bacterial InfectionsH2S, a Bacterial Defense Mechanism against the Host Immune ResponseThe biological mediator hydrogen sulfide (H2S) is produced by bacteria and has been shown to be cytoprotective against oxidative stress and to increase the sensitivity of various bacteria to a range of antibiotic drugs. Here we evaluated whether bacterial H2S provides resistance against the immune response, using two bacterial species that are common sources of nosocomial infections,...
Bacterial InfectionsBrucella neotomae Recapitulates Attributes of Zoonotic Human Disease in a Murine Infection ModelMembers of the genus Brucella are Gram-negative pathogens that cause chronic systemic infection in farm animals and zoonotic infection in humans. Study of the genus Brucella has been hindered by the need for biosafety level 3 select agent containment.
MinireviewThe Evasive Enemy: Insights into the Virulence and Epidemiology of the Emerging Attaching and Effacing Pathogen Escherichia albertiiThe diarrheic attaching and effacing (A/E) pathogen Escherichia albertii was first isolated from infants in Bangladesh in 1991, although the bacterium was initially classified as Hafnia alvei. Subsequent genetic and biochemical interrogation of these isolates raised concerns about their initial...
- Cellular Microbiology: Pathogen-Host Cell Molecular InteractionsThe obligate intracellular bacterium Orientia tsutsugamushi targets NLRC5 to modulate the MHC class-I pathway
- Microbial Immunity and VaccinesSpecific Chicken Egg Yolk Antibody Improves Protective Response against Gallibacterium anatis Infection
- Microbial Immunity and VaccinesA novel, multiple-antigen pneumococcal vaccine protects against lethal Streptococcus pneumoniae challenge